The evaluation of efficacy and adverse effects of subcision in the correction of nasolabial fold
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 10
研究概览
简要总结
The evaluation of efficacy and adverse effects of subcision in the correction of nasolabial fold
Background. A prominent nasolabial fold (NLF) is a cosmetic problem. Currently, numerous therapeutic modalities are available
for pronounced NLFs with variable efficacy. Objective. To determine the efficacy and safety of subcision using a hypodermic needle
for the correction of the prominentNLFs and its effect on skin elasticity. Methods. Sixteen patients with prominentNLFs underwent
subcision. The investigators’ assessment of improvement and the patients’ satisfaction were both recorded 1 and 6 months after the
procedure. Also,we evaluate the skin elasticity of NLFs before and after the treatment using a sensitive biometrologic device with the
measurement of cutaneous resonance running time (CRRT). Results. Thirteen (81.25%) patients showed a moderate improvement
at 1stmonth and 13 (81.25%) patients had at least a mild improvement at 6th month. There was no persistent side effect lasting more
than a few days. Mean CRRT at 1 and 6 months after the treatment was significantly higher compared to the baseline. Conclusion.
Subcision may be considered effective for the correction of pronounced NLFs. However, further controlled studies with larger
sample size are necessary to assess the efficacy of this technique in particular with use ofmore objective assessment of skin biometric
characteristics. This trial is registered with IRCT201108097270N1 (registered on January 27, 2012).
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 30 years 至 60 years（—）
- 性别
- All
入选标准
- •1. age 30-60y; 2.deep nasolabial fold. Exclusion criteria:1.age under 30y; 2.lactation & pregnancy; 3.history of coagulopathy or use of anticouagulant drug; 4.active infection in facial zone; 5.inability to stay in the study; 6.history of collagen or elastin disorder and connective tissue disease; 7.history of facial skin cancer; 8.history of topical medication administration during 1 month before study except sunscreen; 9.history of cosmetic procedure during last year (laser,..); 10. history of filler injection in nasolabial fold during last 5 years.
排除标准
- 未提供