The effect of L-arginine on sexual function and depressio

Phase 3

Recruiting

Conditions: Condition 1: Women's sexual function. Condition 2: Depression.
Decreased libido
Major depressive disorder, single episode
R68.82

Registration Number: IRCT20100127003210N26

Lead Sponsor: Shahid Beheshti University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Female

Target Recruitment: 40

Inclusion Criteria

Patients in the age group of 18-60 years.
Patients are referred to the psychiatric clinic of Taleqani Hospital and Imam Hossein Hospital.
Patients who are diagnosed with major depressive disorder by the DSM-5 diagnostic criteria.
Patients who have the consent to enter the study and complete the consent form.
Patients who have not had a history of taking an antidepressant in the past month before starting current medications.
Patients who do not have autonomic disorders in the genital tract.
Patients who can take oral medications and also likely to complete evaluations.
Patients without active ulcers in the gastrointestinal tract.
People entering the study must be married during the study period.

Exclusion Criteria

Patients who have impaired blood pressure regulation and are taking nitrate-based medications.
Patients with diabetes mellitus
Patients are taking potassium-sparing drugs.
Patients are taking drugs that affect sexual dysfunction and improvement.
Patients who have recently had a heart attack.
Diagnosis of other psychological disorders along with the diagnosis of major depressive disorder or depression with anxiety in the patient.
Consumption of alcohol or drugs or stimulants.
Women who are in a menopausal state when starting the study.
Lack of access or possibility of sexual intercourse with the husband during the study period.

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Sexual function of women. Timepoint: Four weeks before the intervention; Zero, four, and eight weeks after receiving L-arginine. Method of measurement: Rosen et al. questionnaire was used to assess sexual satisfaction for women.

Secondary Outcome Measures

Name	Time	Method
Side effects caused by using L-arginine. Timepoint: In two time periods of four and eight weeks after receiving L-arginine. Method of measurement: The patient complaint, clinical evidence, and symptoms.;Depression. Timepoint: In three time periods of zero, four and eight weeks after receiving L-arginine. Method of measurement: Hamilton questionnaire.