Glycemic Control Following Occupational Work in a Hot Environment

Not Applicable

Not yet recruiting

• Conditions: Plasma Glucose Following Prolonged Heat Exposure

• Registration Number: NCT06982612
• Lead Sponsor: Loughborough University

Brief Summary

Occupational workers regularly perform physically demanding tasks in hot environments, exposing them to heat stress and potential dehydration. While the physiological impacts of heat exposure are well-documented, its effects on glycemic control remain less understood. Given the rising global temperatures due to climate change and the increasing prevalence of metabolic disorders such as obesity and type 2 diabetes, it is essential to investigate how heat exposure during work influences glycemic regulation. Understanding these interactions will help inform future occupational health guidelines and metabolic health recommendations in physically demanding industries.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-05
• Study Start: 2025-05
• Study First Submitted: 2025-05-01
• Study First Submitted QC: 2025-05-18
• Last Update Submitted: 2025-05-18
• Study First Posted: 2025-05-21
• Last Update Posted: 2025-05-21
• Primary Completion: 2026-05-01
• Study Completion: 2026-10-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Male or female
• Generally fit and healthy
• Participate in endurance or intermittent exercise at least 3 times a week or minimum of 150 minutes moderate intensity activity per week

Exclusion Criteria

• Under 18 or 45 and over,
• any morbidity or medication that might influence carbohydrate/fat metabolism (i.e., liver/renal/cardiovascular disease) or cycling ability (musculoskeletal injury etc),
• coagulation or bleeding disorders,
• blood-borne illness,
• heart conditions,
• congenital heart disease,
• uncontrolled exercise-induced asthma,
• smoking (including vaping),
• allergies to the products used in the study,
• dieting or restrained eating behaviours.
• Females with amenorrhea would be an exclusion criteria.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Plasma glucose	8hours	Measured using colorimetric assay from venous blood samples

Secondary Outcome Measures

Name	Time	Method
Plasma insulin	8hours	Measured using ELISA from venous blood samples
Plasma osmolality	8hours	Measured using freezing point depression from venous blood samples
Plasma volume change	8hours	Determined from haemoglobin and haematocrit measures in blood samples
Urine volume	8hours	Determined from urine samples collected before and after exercise
Respiratory gas exchanges	8hours	Measured via Douglas bag, gas content and volume
Body mass	8hours	Determined from weighing participants before and after exercise
Urine specific gravity/osmolality	8hours	Determined from urine samples collected before and after exercise
Rectal temperature	8hours	Measured via rectal probe
Blood pressure	8hours	Measured via and automated sphygmomanometer
Rate of perceived exertion	8hours	using Borg scales (from 6 \[no effort\] to 20 \[maximal effort\])
Rate of thermal sensation	8hours	using -10 \[cold\] to +10 \[hot\] scale.
Feelings of thirst, urge to urinate, GI comfort, and stomach bloatedness	8hours	using scales (0 = no feeling, 10 = extreme feeling)