The effect of laser on radiation-induced xerostomia in patients with head and neck cancer

Not Applicable

• Conditions: Radiation-induced xerostomia.; Dry mouth, unspecified; R68.2

• Registration Number: IRCT20080906001216N3
• Lead Sponsor: vice chancellor of reasearch of Mashhad University of medical sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 13 July 2020

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 34

Inclusion Criteria

Age range:20-75 Yrs
Suffering from head and neck tumors requiring radiotherapy
Involving one of major salivary glands in radiation field
Total dose exceeding 20 Gry

Exclusion Criteria

Patient or physician dissatisfaction
Suffering from minor or major salivary gland tumors
Suffering from any systemic disease with potential of xerostomia or consumption of any drug causing xerostomia
Presence of xerostomia in initial examination(unstimulated saliva<0.1 ml/min)
History of previous radiotherapy
Presence of oral mucosal lesions
Regration of patient during trial

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Stimulated and unstimulated saliva. Timepoint: before radiotherpay and once weekly during radiotherpay ( mean: 6 weeks) on 8 to 10 a.m. Method of measurement: Unstimulated saliva: during 5 minutes,whole saliva was sputed in glass tube (every 60 minutes , 5 times).saliva was measured in mili liters and grams stimulated saliva: saliva stimulation in 0,30,60,90 and 120 seconds by citric acid 2% soaked swab on lateral borders of tongues.