Regulation of Metabolism and Ion Handling

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Behavioral: Speed endurance training

• Registration Number: NCT03317704
• Lead Sponsor: Morten Hostrup, PhD

Brief Summary

This study investigates the relation between ion-handling (K+) and fatigue development during exercise. Before and after a 6-week period of high intensity interval training, performance and ion-handling is assessed in young adults. In addition, mitochondrial function is examined.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-10-03
• Study First Submitted QC: 2017-10-20
• Study First Posted: 2017-10-23
• Study Start: 2017-10-25
• Primary Completion: 2019-12-18
• Study Completion: 2020-05-20
• Status Verified: 2020-09
• Last Update Submitted: 2020-09-09
• Last Update Posted: 2020-09-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 30

Inclusion Criteria

• Healthy men
• 45-55 ml/kg/min
• BMI 19-26 kg/m2
• Normal ECG (assessed by MD)

Exclusion Criteria

• Allergic to n-acetylcystine (NAC) or digoxin
• Severe side effects from NAC or digoxin
• Chronic diseases (assessed by MD to be a potential hazard or to interfere with outcome measures)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
speed endurance training (SET)	Speed endurance training	Training 6 weeks 3 times pr. week
speed endurance training (SET) II	Speed endurance training	Training 6 weeks 3 times pr. week

Primary Outcome Measures

Name	Time	Method
Quadriceps endurance	Change from before (baseline) to after 6 weeks of training (Week 6)	Time to exhaustion during knee-extensor exercise

Secondary Outcome Measures

Name	Time	Method
K+ release	Change from before (baseline) to after 6 weeks of training (Week 6)	Net leg K+ release in mmol/min during knee-extensor exercise

Trial Locations

Locations (1)

University of Copenhagen; 🇩🇰 Copenhagen, Denmark