Progesterone Rise in Agonist Versus Antagonist in Vitro Fertilization (IVF) Cycles
Phase 4
- Conditions
- Pregnancy Outcome After In Vitro Fertilization (IVF)
- Interventions
- Other: In vitro fertilization
- Registration Number
- NCT01191710
- Lead Sponsor
- Universitair Ziekenhuis Brussel
- Brief Summary
The aim is to explore whether the incidence of progesterone rise in the late follicular phase differs between GnRH-agonist and GnRH-antagonist protocols for IVF and whether this has an impact on the probability of pregnancy achievement.
- Detailed Description
In view of the current debate concerning possible differences in efficacy between the two GnRH analogues, the current study aimed to explore whether progesterone control in the late follicular phase differs when GnRH-agonist is used as compared to GnRH-antagonist and if so to what extend does the progesterone rise have an impact on the probability of achieving a pregnancy.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 200
Inclusion Criteria
- age < 39
- follicle-stimulating hormone (FSH) < 12
- gonadotropin dose 100-300IU
Exclusion Criteria
- endometriosis
- known endocrine disorder
- blood analyzed in another laboratory
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Antagonist group In vitro fertilization Antagonist protocol for IVF Agonist group In vitro fertilization Long Agonist protocol for IVF
- Primary Outcome Measures
Name Time Method Incidence of late progesterone rise on the day of HCG triggering Up to delivery (2010)
- Secondary Outcome Measures
Name Time Method Clinical pregnancy rate Delivery rate Up to delivery (2010)
Trial Locations
- Locations (1)
Biogenesis
🇬🇷Thessaloniki, Pylaia, Greece