Effect of Ursolic Acid of Loquat Extract on Function of Muscle
- Conditions
- Sarcopenia
- Registration Number
- NCT02401113
- Lead Sponsor
- Pusan National University Hospital
- Brief Summary
This randomized, placebo-controlled, double-blind study was designed to investigate the efficacy and tolerability of Ursolic Acid of Loquat Extract for treatment of muscle function improvement with relatively health adults. 54 subjects received 500 mg of Loquat Extract per day or a placebo for 12 weeks.
- Detailed Description
This randomized, placebo-controlled, double-blind study was designed to investigate the efficacy and tolerability of Ursolic Acid of Loquat Extract for treatment of muscle function improvement with relatively health adults. 54 subjects received 500 mg of Loquat Extract per day or a placebo for 12 weeks. Change over time in muscle fuction was evaluated by four outcomes: assessment of appendicular skeletal mass using DEXA (dual energy X-ray absorptiometry); quadriceps muscle power by Biodex; hand grib power; and Short Physical Performance Battery, SPPB.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 54
- BMI 18.5-30KG/M2
- > SERUM creatinine 1.2mg/dL
- > AST or ALT 60IU/L
- DM Patients
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method quadriceps muscle function 12weeks
- Secondary Outcome Measures
Name Time Method ASM(appendicular skeletal mass) marker 12weeks Short Physical Performance Battery, SPPB 12weeks
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