Effect of Ursolic Acid of Loquat Extract on Function of Muscle in Human
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 54
- 主要终点
- quadriceps muscle function
研究概览
简要总结
This randomized, placebo-controlled, double-blind study was designed to investigate the efficacy and tolerability of Ursolic Acid of Loquat Extract for treatment of muscle function improvement with relatively health adults. 54 subjects received 500 mg of Loquat Extract per day or a placebo for 12 weeks.
详细描述
This randomized, placebo-controlled, double-blind study was designed to investigate the efficacy and tolerability of Ursolic Acid of Loquat Extract for treatment of muscle function improvement with relatively health adults. 54 subjects received 500 mg of Loquat Extract per day or a placebo for 12 weeks. Change over time in muscle fuction was evaluated by four outcomes: assessment of appendicular skeletal mass using DEXA (dual energy X-ray absorptiometry); quadriceps muscle power by Biodex; hand grib power; and Short Physical Performance Battery, SPPB.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 19 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •BMI 18.5-30KG/M2
排除标准
- •> SERUM creatinine 1.2mg/dL
- •> AST or ALT 60IU/L
- •DM Patients
研究组 & 干预措施
UA group
UA group who takes Ursolic acid of Loquat Extract , 500 mg/ day during 12 weeks for treatment of muscle function improvement with relatively health adults
干预措施: UA group (Dietary Supplement)
placebo group
placebo group who takes a placebo, 500 mg/day for 12 weeks
干预措施: UA group (Dietary Supplement)
结局指标
主要结局
quadriceps muscle function
时间窗: 12weeks
次要结局
- ASM(appendicular skeletal mass) marker(12weeks)
- Short Physical Performance Battery, SPPB(12weeks)
研究者
Sang Yeoup Lee
family medicine
Pusan National University Hospital