Biofortification with zinc in flour for eliminating deficiency

Not Applicable

Completed

• Conditions: ZInc deficiency; Nutritional, Metabolic, Endocrine; Dietary zinc deficiency

• Registration Number: ISRCTN83678069
• Lead Sponsor: niversity of Central Lancashire

Brief Summary

2018 Protocol article in https://www.ncbi.nlm.nih.gov/pubmed/29666141 protocol 2020 Results article in https://doi.org/10.3389/fsufs.2020.00135 results (added 05/11/2020) 2020 Results article in https://doi.org/10.1111/jhn.12791 results (added 10/11/2020) 2017 Results article in https://pubmed.ncbi.nlm.nih.gov/31217749/ (added 20/09/2023) 2020 Results article in https://pubmed.ncbi.nlm.nih.gov/33171944/ (added 20/09/2023) 2022 Results article in https://pubmed.ncbi.nlm.nih.gov/35118107/ (added 20/09/2023)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-08-02
• Study Completion: 2019-04-30
• Last Update Posted: 3 October 2023

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 50

Inclusion Criteria

1. Members of the target community, located on the brick kilns in Peshawar, North West Pakistan
2. Female, aged 16 to 49 years

Exclusion Criteria

Pregnant or lactating women

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Samples are taken for analysis at the end of the equilibration period (week 2), the middle and end of phase 1 (weeks 6 and 10), and the middle and end of crossover phase 2 (weeks 14 and 18):<br>1. Plasma zinc concentration, measured by inductively coupled plasma mass spectrometry (ICP-MS)<br>2. DNA fragmentation, measured using the comet assay<br>3. Hair and nail zinc concentration, measured by laser induced breakdown spectroscopy