Exploratory Analysis of the Relaxation Response (RR) and Mindfulness Based Stress Reduction (MBSR) for Stress Reduction
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- Brain Activity (fMRI) During the Body Scan Meditation
研究概览
简要总结
Currently there are 2 popular stress reduction courses that are widely used in the US. Although they use somewhat similar techniques, it is currently unknown whether or not they work the same way, or if they are similarly effective at reducing stress. The study will directly compare these 2 courses. Participants will undergo approximately 4-5 hours of testing before and after each 8-week course.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 25 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •25 to 60 years old
- •Good general health
- •Able to attend all 8 sessions of the course and practice the techniques each night for 25 minutes
排除标准
- •Psychiatric medications
- •Significant medical or psychological illness
- •Metalic implants (such as a pacemaker or artificial joints) that are not MRI compatible.
- •Claustrophobia
- •Pregnancy
- •Previous head trauma or neurological disorder
- •Previous experience with yoga or meditation
结局指标
主要结局
Brain Activity (fMRI) During the Body Scan Meditation
时间窗: Week 8
Seed based functional connectivity analysis was performed using the Connectivity Toolbox (CONN) implemented within the Statistical Parametric Mapping program (SPM8; Welcome Department of Cognitive Neurology). Our seeds were located in the right inferior frontal gyrus pars opercularis (MNI coordinates: 54, 14, 16) and the dorsal anterior insula (MNI coordinates: 32, 20, 0). Note - MRI data from some subjects was either missing, not collected, or corrupted, and so the analyses were performed on just the subject of subjects who had complete datasets. This assessment reflects the total number of voxels per group.
Five Facet Mindfulness Questionnaire
时间窗: Pre, 8 weeks
The Five Facet Mindfulness Questionnaire (FFMQ) has been developed as a reliable and valid comprehensive instrument for assessing different aspects of mindfulness in community samples. Scores range from 39-195 with higher scores meaning more mindfulness.
Perceived Stress Scale
时间窗: Pre, 8 weeks
The PSS is brief, validated and widely used psychological instrument for assessing a subject's perception of stress change. Scores range from 0-40 with higher scores meaning more stress
Penn State Worry Questionnaire
时间窗: Pre, 8 weeks
The Penn State Worry Questionnaire (PSWQ) is a standard self-report questionnaire that is designed to assess symptoms of General Anxiety Disorder. scores range from 16-80 with higher scores meaning more stress.
Anxiety Severity Index
时间窗: Pre, 8 weeks
the Anxiety Sensitivity Index (ASI) is a measure of individuals discomfort with a variety of sensations associated with anxiety and panic and tends to be substantially higher in those with panic disorder (and attacks) than in those with General Anxiety Disorder. Scores range from 0 - 64. Lower scores mean lower anxiety.
次要结局
- Self Compassion(Pre, week 8)
研究者
Sara W Lazar
Associate Research Scientist
Massachusetts General Hospital