The effect of Volatile induction and maintenance of anesthesia(VIMA) versus Total intravenous anesthesia(TIVA) on the response of pro-inflammatory cytokine during perioperative period of sepsis and septic shock resulting from secondary peritonitis: Prospective study

Not Applicable

Recruiting

Conditions: Symptoms, signs and abnormal clinical and laboratory findings, NEC

Registration Number: KCT0008354

Lead Sponsor: Inje University Haeundae Paik Hospital

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 36

Inclusion Criteria

The inclusion criteria includes age older than 18; American Society of Anesthesiologists
physical status (ASA) score of 1 or 2; and sepsis or septic shock resulted from secondary peritonitis from suspected or proven colorectal origin needing for abnominal surgery.

Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. A change in baseline of the total SOFA score of 2 points or more represents organ dysfunction.
Septic shock is defined as a subset of sepsis in which underlying circulatory and cellularmetabolism abnormalities are profound enough to substantially increase mortality. Septic shock can be identified with a clinical construct of sepsis with persisting hypotension requiring vasopressors to maintain MAP65mmHg and having a serum lactate level >2 mmol/L (18mg/dL) despite adequate volume resuscitation.

Exclusion Criteria

The inclusion criteria includes
age less than 18; American Society of Anesthesiologists physical status (ASA) score more than 3; sepsis or septic shock resulted from secondary peritonitis which in not proved to colorectal origin; sedation state for endotracheal intubation and mechanical ventilation before general anesthesia; need for sedation state for reintubation and mechanical ventilation within 24 hours after surgery and extubation due to deterioration; and pregnancy.

Study & Design

Study Type: Interventional Study

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Interleukin-6

Secondary Outcome Measures

Name	Time	Method
SOFA score, plasma levels of CRP, procalcitonin and lactic acid, vasopressor requirement, durations of mechanical ventilation, ICU length of stay, and 28-day mortality