Investigation of Coagulation Parameters in Hereditary Haemorrhagic Telangiectasia

Completed

• Conditions: Telangiectasia, Hereditary Hemorrhagic
• Interventions: Other: Blood sample to be taken.

• Registration Number: NCT00230659
• Lead Sponsor: Imperial College London

Brief Summary

We will address coagulation parameters in hereditary haemorrhagic telangiectasia (HHT) compared to controls.

Detailed Description

The inherited disease hereditary haemorrhagic telangiectasia (HHT) causes bleeding from dilated fragile vessels, particularly in the nose and gut. However, many HHT patients develop deep venous thromboses and/or pulmonary embolism, necessitating treatments with anticoagulants that further impair control of their haemorrhagic state. Our initial observations using general coagulation tests suggest that the blood of HHT patients is intrinsically hypercoagulable.

We hypothesize that the genetically-determined abnormality in the blood vessels of HHT patients leads to alteration in the concentrations or activity of one or several of the proteins which affect blood clotting leading to a hypercoagulable state.

We propose to study levels and activity of blood coagulation factors in people with hereditary haemorrhagic telangiectasia and in normal volunteers. This should define the significance and basis for our initial observations, and will have significant implications for the clinical management of HHT patients.

Study Timeline

• Study Start: 2004-08
• Study First Submitted: 2005-09-29
• Study First Submitted QC: 2005-09-29
• Study First Posted: 2005-10-03
• Primary Completion: 2007-07
• Study Completion: 2008-07
• Status Verified: 2023-09
• Last Update Submitted: 2023-09-25
• Last Update Posted: 2023-09-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Patients with HHT and normal controls

Exclusion Criteria

• Previous thrombosis, recent ill health

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Controls	Blood sample to be taken.	People without hereditary haemorrhagic telangiectasia. Blood sample to be taken.
HHT patients	Blood sample to be taken.	Patients with hereditary haemorrhagic telangiectasia. Blood sample to be taken.

Trial Locations

Locations (1)

Imperial College Hammersmith Campus; 🇬🇧 London, United Kingdom