Effect of oral betahistin in reducing of nausea and vomiting after surgery
Phase 3
- Conditions
- Postoperative nausea and vomiting.Nausea and vomiting
- Registration Number
- IRCT20201225049829N1
- Lead Sponsor
- Mazandaran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 120
Inclusion Criteria
The patient's desire to participate in the study and gain informed consent
Candidate for elective laparoscopic cholecystectomy
Age between 15 to 60 years
No history of betahistine allergy
No history of gastrointestinal disease and cardiovascular disease and respiratory problems
Exclusion Criteria
Patients with uncontrolled diabetes
Underlying gastrointestinal disease
History of nausea and vomiting and taking anti-nausea and vomiting drugs in 24 hours before surgery
Middle ear disease
Pregnancy
Patients with BMI> 35
High blood pressure, cardiovascular disease, diarrhea with respiratory problems
If the laparoscopic surgery becomes an open cholecystectomy
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Severe nausea. Timepoint: At times 1, 3, 6, 12, 24, 48 after surgery. Method of measurement: NRS (numerical rating scale).;Vomiting. Timepoint: At times 1, 3, 6, 12, 24, 48 after surgery. Method of measurement: NRS (numerical rating scale).
- Secondary Outcome Measures
Name Time Method The amount of ondansetron and narcotics consumed. Timepoint: At times 1, 3, 6, 12, 24 and 48 hours after surgery. Method of measurement: Questionnaire.;Dry mouth. Timepoint: At times 1, 3, 6, 12, 24 and 48 hours after surgery. Method of measurement: Questionnaire.;Headache. Timepoint: At times 1, 3, 6, 12, 24 and 48 hours after surgery. Method of measurement: Questionnaire.;Itching. Timepoint: At times 1, 3, 6, 12, 24 and 48 hours after surgery. Method of measurement: Questionnaire.