KCT0006879
Recruiting
未知
ew treatment criteria for chronic hepatitis B without considering alanine aminotransferase levels to prevent hepatocellular carcinoma
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Asan Medical Center
- Enrollment
- 15000
- Status
- Recruiting
- Last Updated
- 4 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\.Untreated CHB Patient Cohort
- •1\) Adult male or female patients over 20 years of age.
- •2\) Having serum hepatitis B surface antigens for \>6 months
- •3\) Never having any evidence of liver cirrhosis, radiologically, clinically, or both.
- •4\) Serum ALT levels at baseline \<2× upper limit of normal (ULN) \[ULN of ALT \=40 U/L]
- •5\) Never having received HBV treatment, including nucleos(t)ide analogues.
- •2\.Treated CHB Patient Cohort
- •1\) Adult male or female patients over 20 years of age.
- •2\) Having serum hepatitis B surface antigens for \>6 months.
- •3\) Never having any evidence of liver cirrhosis, radiologically, clinically, or both.
Exclusion Criteria
- •1\. Untreated CHB Patient Cohort
- •1\) Patients with evidence of HCV infection, HDV infection or HIV infection.
- •2\) Patients with prior antiviral treatment, malignancy, or immunosuppressive agents.
- •3\) Insufficient medical records.
- •4\) Patients with ALT levels at baseline \>1× ULN and HBV DNA \<2,000 IU/mL.
- •5\) Patients who have received a liver transplantation or have history or evidence of HCC.
- •6\) Patients with ALT elevation \>2× ULN during the initial 1 year of follow\-up.
- •7\) Patients who were followed up less than a year.
- •2\.Treated CHB Patient Cohort
- •1\) Patients with evidence of HCV infection, HDV infection, or HIV infection.
Outcomes
Primary Outcomes
Not specified
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