Cognitive Activation Therapy for MCI: A Randomized Control Study
- Conditions
- Mild Cognitive Impairment
- Interventions
- Behavioral: Waitlist Control / Home-based trainingBehavioral: Cogntive Activation Training
- Registration Number
- NCT01641328
- Lead Sponsor
- Rotman Research Institute at Baycrest
- Brief Summary
Mild cognitive impairment (MCI) describes an initial phase of cognitive decline, usually among older adults, in which a person notices a decline in attention or memory, and performs worse than normal on cognitive tests of such. People with MCI are more likely to develop Alzheimer's disease or related dementia than others their same age, and so MCI is thought of as an early warning sign of progressive cognitive decline.
While some forms of MCI may be brought about by purely genetic causes, other cases may be due to a withdrawal of cognitive engagement with the world. In these cases, a rigorous program of cognitive training may be beneficial, halting or reversing symptom progression.
The current study will evaluate a multifaceted cognitive activation program on older adults with MCI. This group program is intensive, running for 10 weeks, 3 times per week, for a total of 100 hours of training. Training consists of meditation exercises for broad attention activation, Tai Chi exercises to integrate cognition with body awareness, and cognitive training through computerized attention, memory, and problem solving exercise.
Subjective impressions and objective measures of cognitive ability will be measured before and after the intervention. The investigators will also examine effects on mood and levels of daily function. Results will be compared to a waitlisted control group. The control group will subsequently be entered into a home-based version of the program for 10 weeks, with assessment before and after training, to look at the importance of the group meeting dynamic in promoting cognitive change.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 30
- Subjective complaint about decline in memory or attention
- > 1 deviation below age-norm performance on memory or attention tasks
- Independence in daily living
- English speaking
- Neurological disorders (including aphasias) or reversible causes of dementia (e.g., hypothyroidism or B12 deficiency)
- Montreal Cognitive Assessment (MOCA) score < 24
- Clinical mood disorder such as depression or anxiety
- Other serious medical conditions that preclude participation in the program
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Waitlist Control / Home-based training Waitlist Control / Home-based training This group will serve as a waitlist control group while the active group is performing training. Following assessment at the end of the active group period, this group will begin home-based training and will be assessed at the end of that 10 week period. Cognitive Activation Group Cogntive Activation Training This group will attend the 3/week group intervention meetings over 10 weeks.
- Primary Outcome Measures
Name Time Method Attention / Working Memory Before and after intervention Working memory measures such as digit span, selection of targets among distractors, etc.
Processing Speed Before and After Intervention Processing speed on computerized cognitive task.
Executive Function Before and After Intervention Tests of inhibition, task switching, and problem solving.
Memory Before and After Intervention Tests of immediate recall and delayed recall, recognition, and familiarity.
- Secondary Outcome Measures
Name Time Method Daily Function Before and after intervention Tests of instrumental activities of daily living
Mood and Well-being Before and after intervention Tests of dysphoric affect and subjective quality of life
Trial Locations
- Locations (1)
Baycrest
🇨🇦Toronto, Ontario, Canada