Alternative Exercise Program to Improve Skeletal Muscle Function and Fatigue in Cancer Survivors
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 22
- 试验地点
- 2
- 主要终点
- Cross-sectional Area of Skeletal Muscle Fibers
研究概览
简要总结
Exercise training has beneficial effects in cancer survivors to minimize some of the side effects of cancer and its treatment and improve long-term prognosis, but there are numerous hurdles for individuals diagnosed with, and being treated for, cancer to participate in exercise programs. The goal of this research study is to begin to evaluate whether exercise training via neuromuscular electrical stimulation (NMES) has beneficial effects on skeletal muscle size and function in cancer survivors.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 40 Years 至 70 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •stage I, II or III breast cancer
- •receiving neoadjuvant or adjuvant chemotherapy with or without radiation
- •a body mass index <35 kg/m2.
排除标准
- •metastatic disease, a prior history of cancer, excluding non-melanoma skin cancer, or prior receipt of chemotherapy
- •autoimmune, vascular or neuromuscular disease that could alter skeletal muscle
- •prior knee or hip replacement
- •contraindications for use of neuromuscular electrical stimulation, including an implanted cardiac defibrillator or pacemaker, lower extremity blood clot or coagulopathy
结局指标
主要结局
Cross-sectional Area of Skeletal Muscle Fibers
时间窗: Difference between values at baseline at 2 months
Cross-sectional area of skeletal muscle fibers will be evaluated using immunohistochemistry, with specification of all relevant muscle fiber types
Intermyofibrillar Mitochondrial Content
时间窗: Difference between values at baseline at 2 months
Area fraction of intermyofibrillar mitochondria will be assessed by electron microscopy
Maximal Calcium-activated Tension Single Muscle Fiber Tension
时间窗: Difference between values at baseline at 2 months
Tension (force per unit muscle fiber cross-sectional area) from segments of chemically-skinned single human muscle fibers will be assessed under maximal calcium-activated condition, with muscle fiber type determined post-measurement by gel electrophoresis
次要结局
- Single Muscle Fiber Contractile Velocity(Difference between values at baseline at 2 months)
研究者
Michael J. Toth, Ph.D.
Associate Professor of Medicine
University of Vermont