The effect of spirulina supplementation on MS

Phase 3

Conditions: Multiple sclerosis.
Multiple sclerosis

Registration Number: IRCT20240124060794N1

Lead Sponsor: Esfahan University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: All

Target Recruitment: 80

Inclusion Criteria

Patients with MS of RRMS type
Age of patients 18-50 years
Receiving immunosuppressive drugs for at least three months
Not taking multivitamin supplements (except vitamin D) at least 3 months before participating in the study
Having an Extended Disability Status Scale (EDSS) between 0 and 6

Exclusion Criteria

Pregnancy
Presentation of acute forms of liver and biliary system disease and pancreatic disease
History of viral diseases
Chronic renal or cardiovascular disease and diseases where oxidative stress is considered as their etiology
Obese patients (body mass index (BMI) = 30 kg/m2), malnourished patients (BMI < 18.5 kg/m2)
Dependence on drugs, smoking or alcohol
Not taking anticoagulants
Breastfeeding
Hospitalized
Autoimmune diseases that affect the Th1/Th2 balance
Asthma
Diseases in which oxidative stress is proposed as their etiology

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Improve antioxidant status. Timepoint: Before and after supplementation. Method of measurement: Biochemical kit for measurement of antioxidant level.;Improving the quality of life and work. Timepoint: Before and after supplementation. Method of measurement: Quality of life questionnaire.;Improving the speed of nerve transmission. Timepoint: Before and after supplementation. Method of measurement: Skin electrode.

Secondary Outcome Measures