WHISTLER-Online

Conditions: WheezingRespiratory symptomsEducation programPrediction RuleChildren

Registration Number: NL-OMON24646

Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary: 1. Koopman, L. P., Brunekreef, B., de Jongste, J. C. & Neijens, H. J. Definition of respiratory symptoms and disease in early childhood in large prospective birth cohort studies that predict the development of asthma. Pediatr Allergy Immunol 12, 118-124 (2001). 2. Kuehni, C. E., Davis, A., Brooke, A. M. & Silverman, M. Are all wheezing disorders in very young (preschool) children increasing in prevalence? Lancet 357, 1821-1825 (2001). 3. Fuhlbrigge, A. L. et al. The burden of asthma in the United States: level and distribution are dependent on interpretation of the national asthma education and prevention program guidelines. Am. J. Respir. Crit Care Med. 166, 1044-1049 (2002). 4. Guilbert, T. W. et al. Long-term inhaled corticosteroids in preschool children at high risk for asthma. N. Engl. J Med. 354, 1985-1997 (2006). 5. Johnston, S. L. Macrolide antibiotics and asthma treatment. J. Allergy Clin. Immunol. 117, 1233-1236 (2006). 6. Stein, R. T. & Martinez, F. D. Asthma phenotypes in childhood: lessons from an epidemiological approach. Paediatr. Respir. Rev. 5, 155-161 (2004). 7. Katier, N. et al. The Wheezing Illnesses Study Leidsche Rijn (WHISTLER): rationale and design. Eur. J. Epidemiol. 19, 895-903 (2004). 8. De Jong, B. M. et al. Determinants of health care utilization for respiratory symptoms in the first year of life. Med. Care 45, 746-752 (2007). 9. de Jong, B. M. et al. Respiratory symptoms in young infancy: child, parent and physician related determinants of drug prescription in primary care. Ref Type: Unpublished Work 10. Latzin, P. et al. Prospectively assessed incidence, severity, and determinants of respiratory symptoms in the first year of life. Pediatr. Pulmonol. 42, 41-50 (2007). 11. de Jong, B. M. et al. Respiratory symptoms in young infancy: child, parent and physician related determinants of drug prescription in primary care. Ref Type: Unpublished Work 12. de Jong, B. M. et al. Prediction of lower respiratory illness in the first year of life. 2008. Ref Type: Unpublished Work 13. Grimshaw, J. M. et al. Effectiveness and efficiency of guideline dissemination and implementation strategies. Health Technol. Assess. 8, iii-72 (2004). 14. Hunink, M. G. Outcomes research and cost-effectiveness analysis in radiology. Eur. J. Radiol. 27, 85-87 (1998). 15. Cohen, M. G. et al. A simple prediction rule for significant renal artery stenosis in patients undergoing cardiac catheterization. Am. Heart J. 150, 1204-1211 (2005). 16. Mokhlesi, B. et al. Predicting extubation failure after successful completion of a spontaneous breathing trial. Respir. Care 52, 1710-1717 (2007). 17. Verbeke, M., Schrans, D., Deroose, S. & De, M. J. The International Classification of Primary Care (ICPC-2): an essential tool in the EPR of the GP. Stud. Health Technol. Inform. 124, 809-814 (2006). 18. Osman, L. M., Baxter-Jones, A. D. & Helms, P. J. Parents' quality of life and respiratory symptoms in young children with mild wheeze. EASE Study Group. Eur. Respir. J. 17, 254-258 (2001). 19. WMA General Assembly. World medical association declaration of Helsinki. Ethical principles for Medical Research Involving Human Subjects. 2004. Tokyo. Ref Type: Report 20. Ministerie van justitie. Wet van 26 februari 1998, houdende regelen inzake medisch-wetenschappelijk onderzoek met mensen (Wet medisch-wetenschappelijk onderzoek met mensen). 1998. 's Gravenhage, De Minister van Justitie, W. Sorgdrager. Ref Type: Report 21. Federatie van medisch wetenschappelijke verenigingen. Code Goed Gebruik. Beknopte versie onderzoekers. 2002. Ref Type: Report 22. Federatie van medisch wetenschappelijke verenigingen. Gedragscode Gezondheidsonderzoek. Gedragscode van de Nederlandse biomedische onderzoeksgemeenschap goedgekeurd door het College Bescherming Persoonsgegevens in 2004. 2005. Zeist. Ref Type: Report 23. CCMO. CCMO-statement publicatiebeleid. 2002. Ref Type: Report 24. De, A. C. et al. Clinical trial registration: a statement from the International Committee of Medical Journal Editors. N. Engl. J. Med. 351, 1250-1251 (2004).

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 700

Inclusion Criteria

Eligible for the study are families of healthy infants who participate in WHISTLER.

Exclusion Criteria

Exclusion criteria for the WHISTLER-study are gestational age < 36 weeks, major congenital abnormalities and neonatal respiratory disease.

Extra exclusion criteria for WHISTLER-online are the absence of a computer or access to internet or the ignorance of using a computer or internet.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To what extent does the implementation of WHISTLER-online change parental behaviour in primary health care visits, as compared to usual care?

Secondary Outcome Measures

Name	Time	Method
1. To what extent does the implementation of WHISTLER-online change parental behaviour in terms of demand for drug prescriptions, as compared to usual care?<br /><br>2. To what extent does the implementation of WHISTLER-online influence cost-effectiveness of respiratory health care, as compared to usual care?<br /><br>3. What are the main reasons why parents are willing (or not) to use WHISTLER-online in their decision making?<br>