Step-reduction in Older Men and Women

Not Applicable

Completed

• Conditions: Reduced Physical Activity; Older Adults
• Interventions: Behavioral: Normal Daily Steps; Behavioral: Step-Reduction; Behavioral: Return to Normal Daily Steps

• Registration Number: NCT03039556
• Lead Sponsor: McMaster University

Brief Summary

This study investigates the effects of two weeks of reduced daily ambulation and a subsequent return to normal physical activity on metabolic health of older adults.

Detailed Description

Aging results in a progressive loss of muscle mass that is accelerated by periods of muscular disuse, common for older adults during hospitalization or convalescence from illness. Transient physical inactivity has been shown to cause muscular atrophy and impairments in insulin sensitivity in both younger and older adults. However, the recovery capacity of older adults after such physical inactivity remains unknown. This study aims to determine the impact of two weeks of daily step reduction to ≤1000 steps per day, an experimental model mimicking short-term physical inactivity, on glycemic control in older adults and further investigate whether older adults are able to recover from the consequences of this inactivity simply by returning to their habitual activity for 14 days.

Basic Information
|
Recruitment & Eligibility
|
Study & Design
|
Trial Locations

Study Timeline

• Study Start: 2015-09
• Primary Completion: 2016-05
• Study Completion: 2016-05
• Status Verified: 2017-01
• Study First Submitted: 2017-01-13
• Study First Submitted QC: 2017-01-31
• Last Update Submitted: 2017-01-31
• Study First Posted: 2017-02-01
• Last Update Posted: 2017-02-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 22

Inclusion Criteria

• Non-smoker

Read More

Exclusion Criteria

• Use of assistive walking devices
• Chronic use of analgesic or anti-inflammatory drugs
• History of neuromuscular problems or muscle and/or bone wasting disease
• Acute or chronic illness including cardiac, pulmonary, liver or kidney abnormalities, uncontrolled hypertension, insulin or non-insulin dependent diabetes or other metabolic disorders
• Daily use of statins, particularly simvastatin and atorvastatin
• Use of medications known to affect protein metabolism
• Normally complete fewer than 3000 steps per day

Read More

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Change in physical activity for older adults	Return to Normal Daily Steps	Older adult participants undergo alterations in daily ambulation by completing Normal Daily Steps for one week, followed by a two-week Step-Reduction and a subsequent Return to Normal Daily Steps for two weeks
Change in physical activity for older adults	Normal Daily Steps	Older adult participants undergo alterations in daily ambulation by completing Normal Daily Steps for one week, followed by a two-week Step-Reduction and a subsequent Return to Normal Daily Steps for two weeks
Change in physical activity for older adults	Step-Reduction	Older adult participants undergo alterations in daily ambulation by completing Normal Daily Steps for one week, followed by a two-week Step-Reduction and a subsequent Return to Normal Daily Steps for two weeks

Primary Outcome Measures

Name	Time	Method
Change in Insulin Sensitivity	Measured at the end of each behavioural intervention (Week 1, Week 3, Week 5)	Assessed via Matsuda ISI

Secondary Outcome Measures

Name	Time	Method
Change in Muscle Protein Synthesis	Measured at the end of each behavioural intervention (Week 1, Week 3, Week 5)	Obtained via vastus lateralis muscle biopsy
Change in lean tissue mass	Measured at the end of each behavioural intervention (Week 1, Week 3, Week 5)	Assessed via Dual Energy X-Ray Absorptiometry
Change in Peak Isometric Maximal Voluntary Leg Extension Strength	Measured at the end of each behavioural intervention (Week 1, Week 3, Week 5)	Assessed via muscle dynamometry

Trial Locations

Locations (1)

Exercise Metabolism Research Laboratory, McMaster Univeristy; 🇨🇦 Hamilton, Ontario, Canada