The Influence of Acute Physical Inactivity on Metabolic Function in Older Men and Women
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Older Adults
- Sponsor
- McMaster University
- Enrollment
- 22
- Locations
- 1
- Primary Endpoint
- Change in Insulin Sensitivity
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
This study investigates the effects of two weeks of reduced daily ambulation and a subsequent return to normal physical activity on metabolic health of older adults.
Detailed Description
Aging results in a progressive loss of muscle mass that is accelerated by periods of muscular disuse, common for older adults during hospitalization or convalescence from illness. Transient physical inactivity has been shown to cause muscular atrophy and impairments in insulin sensitivity in both younger and older adults. However, the recovery capacity of older adults after such physical inactivity remains unknown. This study aims to determine the impact of two weeks of daily step reduction to ≤1000 steps per day, an experimental model mimicking short-term physical inactivity, on glycemic control in older adults and further investigate whether older adults are able to recover from the consequences of this inactivity simply by returning to their habitual activity for 14 days.
Investigators
Stuart Phillips
Professor
McMaster University
Eligibility Criteria
Inclusion Criteria
- •Non-smoker
Exclusion Criteria
- •Use of assistive walking devices
- •Chronic use of analgesic or anti-inflammatory drugs
- •History of neuromuscular problems or muscle and/or bone wasting disease
- •Acute or chronic illness including cardiac, pulmonary, liver or kidney abnormalities, uncontrolled hypertension, insulin or non-insulin dependent diabetes or other metabolic disorders
- •Daily use of statins, particularly simvastatin and atorvastatin
- •Use of medications known to affect protein metabolism
- •Normally complete fewer than 3000 steps per day
Outcomes
Primary Outcomes
Change in Insulin Sensitivity
Time Frame: Measured at the end of each behavioural intervention (Week 1, Week 3, Week 5)
Assessed via Matsuda ISI
Secondary Outcomes
- Change in Muscle Protein Synthesis(Measured at the end of each behavioural intervention (Week 1, Week 3, Week 5))
- Change in lean tissue mass(Measured at the end of each behavioural intervention (Week 1, Week 3, Week 5))
- Change in Peak Isometric Maximal Voluntary Leg Extension Strength(Measured at the end of each behavioural intervention (Week 1, Week 3, Week 5))