The Influence of Acute Physical Inactivity on Metabolic Function in Older Men and Women
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 22
- 试验地点
- 2
- 主要终点
- Change in Insulin Sensitivity
研究概览
简要总结
This study investigates the effects of two weeks of reduced daily ambulation and a subsequent return to normal physical activity on metabolic health of older adults.
详细描述
Aging results in a progressive loss of muscle mass that is accelerated by periods of muscular disuse, common for older adults during hospitalization or convalescence from illness. Transient physical inactivity has been shown to cause muscular atrophy and impairments in insulin sensitivity in both younger and older adults. However, the recovery capacity of older adults after such physical inactivity remains unknown. This study aims to determine the impact of two weeks of daily step reduction to ≤1000 steps per day, an experimental model mimicking short-term physical inactivity, on glycemic control in older adults and further investigate whether older adults are able to recover from the consequences of this inactivity simply by returning to their habitual activity for 14 days.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 65 Years 至 80 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Non-smoker
排除标准
- •Use of assistive walking devices
- •Chronic use of analgesic or anti-inflammatory drugs
- •History of neuromuscular problems or muscle and/or bone wasting disease
- •Acute or chronic illness including cardiac, pulmonary, liver or kidney abnormalities, uncontrolled hypertension, insulin or non-insulin dependent diabetes or other metabolic disorders
- •Daily use of statins, particularly simvastatin and atorvastatin
- •Use of medications known to affect protein metabolism
- •Normally complete fewer than 3000 steps per day
结局指标
主要结局
Change in Insulin Sensitivity
时间窗: Measured at the end of each behavioural intervention (Week 1, Week 3, Week 5)
Assessed via Matsuda ISI
次要结局
- Change in Muscle Protein Synthesis(Measured at the end of each behavioural intervention (Week 1, Week 3, Week 5))
- Change in lean tissue mass(Measured at the end of each behavioural intervention (Week 1, Week 3, Week 5))
- Change in Peak Isometric Maximal Voluntary Leg Extension Strength(Measured at the end of each behavioural intervention (Week 1, Week 3, Week 5))
研究者
Stuart Phillips
Professor
McMaster University