Evaluation of Autogenous Demineralized Dentin Graft for Ridge Preservation With and Without Injectable Platelet Rich Fibrin

Not Applicable

Completed

• Conditions: Ridge Preservation; Alveolar Bone Loss; Dentin Graft
• Interventions: Procedure: demineralized dentin graft; Procedure: injectable platelet rich fibrin with demineralized dentin graft

• Registration Number: NCT05437172
• Lead Sponsor: Cairo University

Brief Summary

Ridge preservation should be considered whenever possible after tooth extraction. Whether implant placement would be performed or for aesthetic consideration at pontic sites when conventional bridge is planned. Ridge preservation aims to maximize the bone formation accompanied with good soft tissue architecture to facilitate implant and prosthetic replacement restoring function, phonetics and aesthetics. the Aim of the study is To evaluate the bucco-lingual ridge width clinically and radiographically, height of buccal and lingual ridges of the socket after application of injectable platelet rich fibrin and autogenous dentin graft.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-06-23
• Study First Submitted QC: 2022-06-27
• Study First Posted: 2022-06-29
• Study Start: 2022-06-30
• Primary Completion: 2023-07-01
• Study Completion: 2023-12-15
• Status Verified: 2025-02
• Last Update Submitted: 2025-02-11
• Last Update Posted: 2025-02-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

• Age ≥ 18 years need of at least one single rooted tooth extraction.
• Non-restorable teeth.
• Systemically healthy patients.
• Good oral hygiene, Plaque index less than 15%.
• Non-smoker or Smoking ≤ 10 cigarettes/day.
• Cooperative patients able and accept to come for follow up appointments.

Exclusion Criteria

• Any interim intervention that may have affected any of the outcomes of interest.
• Pregnant and lactation females.
• Smoking ˃ 10 cigarettes/day.
• Patients reporting systemic conditions that may compromise healing or bone metabolism (eg: diabetes).
• Patients with poor oral hygiene.
• Any known allergies.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
deminerlized dentin graft	demineralized dentin graft	deminerlized dentin graft for ridge preservation after teeth extraction
injectable platelet rich fibrin with deminerlized dentin graft	injectable platelet rich fibrin with demineralized dentin graft	injectable platelet rich fibrin with deminerlized dentin graft for ridge preservation after teeth extraction

Primary Outcome Measures

Name	Time	Method
Radiographic Bucco-lingual ridge width change	up to 24 weeks	radiographic measurement

Secondary Outcome Measures

Name	Time	Method
Changes in the height of the socket buccal and lingual ridges.	up to 24 weeks	radiographic measurement
postoperative pain	immediately after the procedure	Visual analogue scale from zero (better) to 10 (worse)
Keratinized tissue width	up to 24 weeks	periodontal probe measurement
chair time	immediately after the procedure	in minutes
Patient satisfaction	immediately after the procedure	binary yes and no

Trial Locations

Locations (1)

Faculty of Dentistry, Cairo University; 🇪🇬 Cairo, Manial, Egypt