Investigating the relationship between blood pressure and gut permeability in normotensive and hypertensive patients

A/Prof Francine Marques0 个研究点目标入组 96 人开始时间: 2024年2月8日最近更新: 2024年8月12日

适应症

试验速览

暂无简介。

•Ability to give informed consent.
•18-75 years of age
•BMI 18.5-40 kg/m2
•Either sex
•For normotensive participants:
•- Not taking antihypertensive medications AND
•- 24 hour ambulatory blood pressure monitoring results of Systolic blood pressure <130 mmHg and diastolic blood pressure <80 mmHg
•For untreated hypertensive participants:
•- Not taking antihypertensive medications AND
•- 24 hour ambulatory blood pressure monitoring results of Systolic blood pressure >130 mmHg and diastolic blood pressure >80 mmHg
•For treated hypertensive participants:
•- Taking 1-2 antihypertensive medications, regardless of blood pressure results
•- Taking 3 or more antihypertensive medications including a diuretic AND
•-24 hour ambulatory blood pressure monitoring results of Systolic blood pressure <130 mmHg and diastolic blood pressure <80 mmHg
•For resistant hypertensive participants:
•- Taking 3 or more antihypertensive medications including a diuretic AND
•- 24 hour ambulatory blood pressure monitoring results of Systolic blood pressure >130 mmHg and diastolic blood pressure >80 mmHg

•Alzheimers, dementia or other unsoundness of mind
•Recent use of antibiotics (<3 months) or probiotics (< 6 weeks)
•Pregnant or lactating women
•Presence of gastrointestinal diseases (including ulcerative colitis, crohn’s disease, inflammatory bowel disease, lactose intolerance, celiac disease, chronic pancreatitis or other malabsorption disorder).
•Previous gastrointestinal surgery.
•Renal dysfunction with an eGFR < 45.
•ADHD stimulant medications (as this may affect blood pressure)
•Office blood pressure over/equal to 165/100 mmHg – these participants will be advised to see their GPs as guidelines suggest antihypertensive therapy should be started soon.

发起方

A/Prof Francine Marques