ACTRN12624000112561
Recruiting
N/A
Investigating the relationship between blood pressure and gut permeability in normotensive and hypertensive patients
A/Prof Francine Marques0 sites96 target enrollmentFebruary 8, 2024
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- High Blood Pressure
- Sponsor
- A/Prof Francine Marques
- Enrollment
- 96
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Ability to give informed consent.
- •18\-75 years of age
- •BMI 18\.5\-40 kg/m2
- •Either sex
- •For normotensive participants:
- •\- Not taking antihypertensive medications AND
- •\- 24 hour ambulatory blood pressure monitoring results of Systolic blood pressure \<130 mmHg and diastolic blood pressure \<80 mmHg
- •For untreated hypertensive participants:
- •\- Not taking antihypertensive medications AND
- •\- 24 hour ambulatory blood pressure monitoring results of Systolic blood pressure \>130 mmHg and diastolic blood pressure \>80 mmHg
Exclusion Criteria
- •Alzheimers, dementia or other unsoundness of mind
- •Recent use of antibiotics (\<3 months) or probiotics (\< 6 weeks)
- •Pregnant or lactating women
- •Presence of gastrointestinal diseases (including ulcerative colitis, crohn’s disease, inflammatory bowel disease, lactose intolerance, celiac disease, chronic pancreatitis or other malabsorption disorder).
- •Previous gastrointestinal surgery.
- •Renal dysfunction with an eGFR \< 45\.
- •ADHD stimulant medications (as this may affect blood pressure)
- •Office blood pressure over/equal to 165/100 mmHg – these participants will be advised to see their GPs as guidelines suggest antihypertensive therapy should be started soon.
Outcomes
Primary Outcomes
Not specified
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