Investigating high blood pressure and gut leakiness

Not Applicable

Recruiting

• Conditions: High Blood Pressure; Hypertension; Gastrointestinal permeability; Cardiovascular - Hypertension; Oral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon

• Registration Number: ACTRN12624000112561
• Lead Sponsor: A/Prof Francine Marques

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-02-08
• Last Update Posted: 12 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 96

Inclusion Criteria

•Ability to give informed consent.
•18-75 years of age
•BMI 18.5-40 kg/m2
•Either sex

For normotensive participants:
- Not taking antihypertensive medications AND
- 24 hour ambulatory blood pressure monitoring results of Systolic blood pressure <130 mmHg and diastolic blood pressure <80 mmHg

For untreated hypertensive participants:
- Not taking antihypertensive medications AND
- 24 hour ambulatory blood pressure monitoring results of Systolic blood pressure >130 mmHg and diastolic blood pressure >80 mmHg

For treated hypertensive participants:
- Taking 1-2 antihypertensive medications, regardless of blood pressure results
OR
- Taking 3 or more antihypertensive medications including a diuretic AND
-24 hour ambulatory blood pressure monitoring results of Systolic blood pressure <130 mmHg and diastolic blood pressure <80 mmHg

For resistant hypertensive participants:
- Taking 3 or more antihypertensive medications including a diuretic AND
- 24 hour ambulatory blood pressure monitoring results of Systolic blood pressure >130 mmHg and diastolic blood pressure >80 mmHg

Exclusion Criteria

•Alzheimers, dementia or other unsoundness of mind
•Recent use of antibiotics (<3 months) or probiotics (< 6 weeks)
•Pregnant or lactating women
•Presence of gastrointestinal diseases (including ulcerative colitis, crohn’s disease, inflammatory bowel disease, lactose intolerance, celiac disease, chronic pancreatitis or other malabsorption disorder).
•Previous gastrointestinal surgery.
•Renal dysfunction with an eGFR < 45.
•ADHD stimulant medications (as this may affect blood pressure)
•Office blood pressure over/equal to 165/100 mmHg – these participants will be advised to see their GPs as guidelines suggest antihypertensive therapy should be started soon.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Degree of gut permeability<br>[Multisugar Test 24 urine will be collected following administration of the multisugar test drink at study visit 2. This will be approximately 3-7 days post study enrolment, depending on when participant schedules this appointment.]