Efficacy of Administration of ACE-Inhibition on Autonomic and Peripheral Neuropathy in Patients With Diabetes Mellitus

Phase 4

Completed

• Conditions: Diabetic Autonomic Neuropathy

• Registration Number: NCT03031834
• Lead Sponsor: Aristotle University Of Thessaloniki

Brief Summary

Patients with diabetes mellitus and definite autonomic and peripheral neuropathy were randomized to receive quinapril or no treatment for 2 years.

Detailed Description

Not available

Study Timeline

• Study Start: 1999-01
• Primary Completion: 2001-05
• Status Verified: 2017-01
• Study First Submitted: 2017-01-12
• Study First Submitted QC: 2017-01-24
• Last Update Submitted: 2017-01-24
• Study First Posted: 2017-01-26
• Last Update Posted: 2017-01-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• Diabetes mellitus with both autonomic and peripheral neuropathy

Exclusion Criteria

• Hypertension, coronary heart disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Changes in R-R variation during deep breathing	2 years
Changes in response to Valsalva maneuver	2 years
Changes in 30:15 ratio	2 years
Changes in blood pressure response to standing	2 years