Comparison of Volume Controlled Ventilation and Autoflow-volume Controlled Ventilation in Robot-assisted Laparoscopic Radical Prostatectomy With Steep Trendelenburg Position and Pneumoperitoneum
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- arterial oxygen tension (PaO2)
研究概览
简要总结
The steep trendelenburg position and pneumoperitoneum during laparoscopic surgery have the potential to cause an adverse effects on respiratory mechanics and gas exchange. Autoflow-volume controlled ventilation may improve lung compliance and reduce airway peak pressure. Therefore, the aim of this study is to evaluate whether Autoflow-volume controlled ventilation improves gas exchange and respiratory mechanics in patients undergoing robot-assisted laparoscopic radical prostatectomy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult male patients scheduled for elective robot-assisted laparoscopic radical prostatectomy undergoing general anesthesia
排除标准
- •chronic obstructive respiratory diseases
- •heart failure
- •body mass index (BMI >30 kg/m2)
研究组 & 干预措施
Volume controlled ventilation
During the steep trendelenburg position and pneumoperitoneum, volume controlled ventilation will be applied with 8ml/kg (ideal body weight) and inspiration:expiration ratio (I:E) = 1:2.
干预措施: Volume controlled ventilation (Other)
Autoflow-volume controlled ventilation
During the steep trendelenburg position and pneumoperitoneum, Autoflow-volume controlled ventilation will be applied with 8ml/kg (ideal body weight) and inspiration:expiration ratio (I:E) = 1:2.
干预措施: Autoflow-volume controlled ventilation (Other)
结局指标
主要结局
arterial oxygen tension (PaO2)
时间窗: 30 minutes after steep trendelenburg position and pneumoperitoneum.
Arterial oxygen tension (PaO2) obtained from arterial blood gas analysis
次要结局
- The peak inspiratory pressure(10 minutes after anesthesia induction, 30 and 60 minutes after steep trendelenburg position and pneumoperitoneum, and 10 minutes after supine position and CO2 desufflation.)