Motor Slowing and Its Lesion-related Correlates in Alzheimer's Disease

Not Applicable

Recruiting

• Conditions: Alzheimer Disease

• Registration Number: NCT02811653
• Lead Sponsor: Centre Hospitalier Universitaire, Amiens

Brief Summary

In AD (Alzheimer disease), the anatomic correlates of attention disorders (as evaluated by motor slowing) have not been thoroughly characterized.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-12-01
• Study First Submitted: 2016-06-16
• Study First Submitted QC: 2016-06-22
• Study First Posted: 2016-06-23
• Status Verified: 2023-03
• Last Update Submitted: 2023-03-21
• Last Update Posted: 2023-03-22
• Primary Completion: 2023-12-01
• Study Completion: 2023-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 155

Inclusion Criteria

• Patients

  • Age between 40 and 85
  • French mother tongue
  • Consulting at the Amiens Memory Resource and Research Centre (CMRR) for:
  • MCI, according to Albert et al.'s criteria (Albert et al., 2011)
  • Mild dementia (MMSE>20) due to AD, according to McKhann's criteria (McKhann et al., 2011).
  • Mild dementia due to LBD, according to McKeith et al.'s criteria (McKeith et al., 2005).
  • Mild dementia due to FTLD, according to Rascovsky et al.'s criteria (Rascovsky et al., 2011).
  • Social security coverage

• Healthy controls

  • Healthy age and gender matched volunteers will be recruited into the study from the general population.

Exclusion Criteria

• Reading or writing difficulties related to a learning disorder or illiteracy.

• A medical history with a potentially significant impact on cognition (non-corrected thyroid disorders or heart failure):

  • NYHA stage IV dyspnoea.
  • respiratory impairment requiring oxygen therapy.
  • liver impairment.
  • kidney failure, progressing neoplastic disease, or past or present alcohol abuse.

• Past or present neurological disorders other than those having prompted consultation in the Memory Clinic:

  • stroke.
  • meningitis or encephalitis.
  • severe head injury.
  • sensorimotor impairments (sensory, proprioceptive, cerebellar and visual impairments).
  • epilepsy (requiring ongoing treatment),
  • psychiatric disorders (other than treated depression).
  • treatment with psychotropic medications (other than anxiolytics or antidepressant withdrawn or initiated in the previous month). Patients with parkinsonian syndrome were examined in the "on-drug" state.

• Impossibility to perform a neuropsychological evaluation or brain MRI.

• Withdrawal from the study at any time, if desired.

• Pregnancy

• Contra-indication to MRI:

  • nerve stimulators
  • cochlear implants
  • ferromagnetic foreign bodies close to nervous structures in the eye or brain
  • cerebral shunts
  • dental appliances

• Legal guardianship or incarceration.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
median SRT (simple reaction time) to a stimulus (in milliseconds)	Day 0

Trial Locations

Locations (1)

CHU Amiens; 🇫🇷 Amiens, France