Motor Slowing and Its Lesion-related Correlates in Alzheimer's Disease

Centre Hospitalier Universitaire, Amiens1 site in 1 country155 target enrollmentDecember 1, 2015

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Alzheimer Disease
Sponsor: Centre Hospitalier Universitaire, Amiens
Enrollment: 155
Locations: 1
Primary Endpoint: median SRT (simple reaction time) to a stimulus (in milliseconds)
Status: Recruiting
Last Updated: 3 years ago

In AD (Alzheimer disease), the anatomic correlates of attention disorders (as evaluated by motor slowing) have not been thoroughly characterized.

Registry

clinicaltrials.gov

Start Date

December 1, 2015

End Date

December 2023

Last Updated

3 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Sponsor

Responsible Party

Sponsor

•Age between 40 and 85
•French mother tongue
•Consulting at the Amiens Memory Resource and Research Centre (CMRR) for:
•MCI, according to Albert et al.'s criteria (Albert et al., 2011)
•Mild dementia (MMSE\>20) due to AD, according to McKhann's criteria (McKhann et al., 2011).
•Mild dementia due to LBD, according to McKeith et al.'s criteria (McKeith et al., 2005).
•Mild dementia due to FTLD, according to Rascovsky et al.'s criteria (Rascovsky et al., 2011).
•Social security coverage
•Healthy controls
•Healthy age and gender matched volunteers will be recruited into the study from the general population.

•Reading or writing difficulties related to a learning disorder or illiteracy.
•A medical history with a potentially significant impact on cognition (non-corrected thyroid disorders or heart failure):
•NYHA stage IV dyspnoea.
•respiratory impairment requiring oxygen therapy.
•liver impairment.
•kidney failure, progressing neoplastic disease, or past or present alcohol abuse.
•Past or present neurological disorders other than those having prompted consultation in the Memory Clinic:
•meningitis or encephalitis.
•severe head injury.
•sensorimotor impairments (sensory, proprioceptive, cerebellar and visual impairments).