The Effect of Laparoscopic Splenectomy and Azygoportal Disconnection on Liver Reserve Function for Cirrhosis Patients
- Conditions
- Portal HypertensionCirrhosis, LiverSplenectomy; Status
- Interventions
- Procedure: Laparoscopic splenectomy and azygoportal disconnection
- Registration Number
- NCT05325437
- Lead Sponsor
- Northern Jiangsu People's Hospital
- Brief Summary
In this study, the investigators compared the improvement of liver reserve function related indicators in patients with liver cirrhosis after laparoscopic splenectomy and azygoportal disconnection. To determine whether surgical treatment can help enhance postoperative liver reserve function and improve patient prognosis.
- Detailed Description
The patients were enrolled according to the research criteria, and collected the general basic information of the patients. After the preoperative preparation was perfected, the same surgical team performed laparoscopic splenectomy and azygoportal disconnection, and the same nursing team performed the nursing after the operation. Then, patients received a unified treatment plan after surgery, including medication, other treatments and follow-up. During the treatment, the liver reserve function related indicators of the patients were monitored before surgery, 3, 6, 12 and 24 months after surgery, including TBIL, DBIL, ALB, ALT, INR, PT, Child-Pugh, ascites, prealbumin, ICG-K, ICG-R 15 and ICG-T/2.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 20
- A clinical, radiological or histologic diagnosis of cirrhosis of any etiology
- Splenomegaly with secondary hypersplenism
- gastroesophageal variceal bleeding
- Informed consent to participate in the study
- Hepatocellular carcinoma or any other malignancy,
- Child-Pugh grade C
- Recent peptic ulcer disease
- History of Hemorrhagic stroke
- Pregnancy.
- Uncontrolled Hypertension
- Human immunodeficiency virus (HIV) infection
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Experimental Group Laparoscopic splenectomy and azygoportal disconnection Laparoscopic splenectomy and azygoportal disconnection
- Primary Outcome Measures
Name Time Method Liver reserve function ICG-K at 3 months after surgery. 3 months The level of liver reserve function ICG-K at 3 months after surgery.
Liver reserve function ICG-T/2 at 6 months after surgery. 6 months The level of liver reserve function ICG-T/2 at 6 months after surgery.
Liver reserve function ICG-K at 6 months after surgery. 6 months The level of liver reserve function ICG-K at 6 months after surgery.
Liver reserve function ICG-K at 24 months after surgery. 24 months The level of liver reserve function ICG-K at 24 months after surgery.
Liver reserve function ICG-R 15 at 3 months after surgery. 3 months The level of liver reserve function ICG-R 15 at 3 months after surgery.
Liver reserve function ICG-T/2 at 24 months after surgery. 24 months The level of liver reserve function ICG-T/2 at 24 months after surgery.
Liver reserve function ICG-R 15 at 6 months after surgery. 6 months The level of liver reserve function ICG-R 15 at 6 months after surgery.
Liver reserve function ICG-T/2 at 3 months after surgery. 3 months The level of liver reserve function ICG-T/2 at 3 months after surgery.
Liver reserve function ICG-K at 12 months after surgery. 12 months The level of liver reserve function ICG-K at 12 months after surgery.
Liver reserve function ICG-R 15 at 12 months after surgery. 12 months The level of liver reserve function ICG-R 15 at 12 months after surgery.
Liver reserve function ICG-R 15 at 24 months after surgery. 24 months The level of liver reserve function ICG-R 15 at 24 months after surgery.
Liver reserve function ICG-T/2 at 12 months after surgery. 12 months The level of liver reserve function ICG-T/2 at 12 months after surgery.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Clinical Medical College of Yangzhou University
🇨🇳Yangzhou, Jiangsu, China