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Clinical Trials/NCT05968820
NCT05968820
Recruiting
Phase 1

Tailoring a Sleep Health Enhancement Intervention for Older Adults to Address Frailty

University of Kansas Medical Center1 site in 1 country40 target enrollmentSeptember 12, 2023
ConditionsFrailty

Overview

Phase
Phase 1
Intervention
Not specified
Conditions
Frailty
Sponsor
University of Kansas Medical Center
Enrollment
40
Locations
1
Primary Endpoint
6-item Acceptability Scale
Status
Recruiting
Last Updated
last year

Overview

Brief Summary

The objective of the proposed study is to tailor a sleep health enhancement intervention to older adults and assess preliminary efficacy on reducing frailty in older adults. This pilot study will be conducted in two stages. In the treatment development stage, we will recruit n=10 older individuals age ≥65 with poor sleep health (≤ 7 on the Ru-SATED self-report questionnaire) to assess acceptability and tailor the sleep health enhancement intervention for older adults. In the pilot study stage to assess preliminary efficacy of the tailored sleep health enhancement intervention, n=30 older adults with poor sleep health will be randomly assigned to a 4-week 1x/week, telehealth-delivered sleep health enhancement intervention or to a wait-list control condition. Participants will wear wrist-worn actigraphy, complete sleep, frailty, and quality of life questionnaires at baseline and reassessments.

Registry
clinicaltrials.gov
Start Date
September 12, 2023
End Date
August 2024
Last Updated
last year
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Catherine Siengsukon, PT, PhD

Professor

University of Kansas Medical Center

Eligibility Criteria

Inclusion Criteria

  • ≥65 years old
  • ≤ 7 on the RU-SATED self-report questionnaire
  • MMSE ≥25 and AD8 \<3

Exclusion Criteria

  • Known untreated sleep disorder (such as sleep apnea or restless leg syndrome)
  • \>3 on the STOP BANG indicating increased risk of sleep apnea
  • Evidence of restless legs syndrome on RLS-Diagnosis Index
  • Evidence of circadian rhythm sleep-wake disorder
  • Evidence of parasomnia
  • Regular use (\>2x/week) of prescription or over-the-counter medications to improve sleep
  • Score of ≥15 on the Patient Health Questionnaire (PHQ-9) indicating severe depression or endorse any suicidal ideation (answer 1, 2 or 3 on #9 of the PHQ-9)
  • Score of ≥10 on the Generalized Anxiety Disorder (GAD-7) indicating moderate to severe anxiety
  • Self-report of current or history (up to 2 years) of drug or alcohol abuse based on the DSM-V criteria
  • History of nervous system disorder such as stroke or Parkinson's disease

Outcomes

Primary Outcomes

6-item Acceptability Scale

Time Frame: 6 week

5-point Likert scale on ease of use, understandability, enjoyment, perceived helpfulness, time commitment, and overall satisfaction

semi-standardized qualitative interview

Time Frame: 6 week

Feasibility and acceptability will be assessed via semi-structured interview with a trained graduate research assistant following standard qualitative methods to determine attitudes, perceptions and experiences of effectiveness, potential barriers, benefits, and likes/dislikes of the sleep health enhancement intervention. The interview will be recorded for analysis purposes

WHOQOL-BREF

Time Frame: baseline, 6 week and 12 week reassessments

The WHOQOL-BREF consists of 26 items and 4 domains of quality of life (psychological, physical health, social relationships and environmental). Scores range from 4-20 for each domain and a higher score indicates higher quality of life.

Ru_SATED sleep health composite

Time Frame: baseline, 6 week and 12 week reassessments

Ru-SATED sleep health composite will be calculated using actigraphy data and self-report questionnaires. The domains will be summed to create the composite sleep health score ranging from 0-6 with a higher score indicating better sleep health.

Tilburg Frailty Indicator

Time Frame: baseline, 6 week and 12 week reassessments

The Tilburg Frailty Indicator consists of 15 questions with score ranging from 0-15 with a higher score indicating higher level of frailty. The physical, psychological, and social frailty sub scores range from 0-8, 0-4, and 0-3 respectively.

Secondary Outcomes

  • Pittsburgh Sleep Quality Index(baseline, 6 week and 12 week reassessments)
  • Epworth Sleepiness Scale(baseline, 6 week and 12 week reassessments)
  • Dysfunctional Beliefs About Sleep(baseline, 6 week and 12 week reassessments)
  • Actigraphy(baseline, 6 week and 12 week reassessments)
  • Sleep Self-Efficacy(baseline, 6 week and 12 week reassessments)

Study Sites (1)

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