New Imaging and Diagnostic Techniques for the Assessment of Reperfusion Injury in Myocardial Infarction.
Overview
- Phase
- Not Applicable
- Intervention
- contrast echocardiography
- Conditions
- Reperfusion Injury
- Sponsor
- RWTH Aachen University
- Enrollment
- 200
- Locations
- 1
- Status
- Completed
- Last Updated
- 17 years ago
Overview
Brief Summary
The primary purpose of this study is to correlate new cardiac imaging modalities (2D, 3D echocardiography, contrast echocardiography, strain analysis and cardiac MRI) to biochemical parameters as the L-arginine-nitric oxide pathway and inflammatory cascades to characterize the reperfusion injury following myocardial infarction and thus providing a basis for further diagnostic and therapeutic approaches.
Detailed Description
By reperfusion of ischemic myocardium further tissue damage occurs (ischemia / reperfusion injury). Various contributing mechanisms have been discussed in experimental studies, e.g. disturbances in coronary microcirculation and consecutive induction of inflammatory cascades involving formation of reactive oxygen species. The ischemia / reperfusion injury causes diastolic and regional as well as global systolic dysfunction. The time course of the reperfusion injury within the first hours after reperfusion and its effects on the global geometry of the left ventricle have not been investigated so far. In the present study a comprehensive morphological and functional characterisation of the ischemia / reperfusion injury in the acute phase is performed. New cardiac imaging modalities (2D, 3D echocardiography, contrast echocardiography, strain analysis and cardiac MRI)and biochemical parameters including the L-arginine-nitric oxide pathway and inflammatory cascades are applied. Hereby morphological and biochemical markers for the functional recovery of myocardial function should be identified.
Investigators
Eligibility Criteria
Inclusion Criteria
- •patients with acute ST elevation myocardial infarction and consecutive percutaneous coronary intervention of the infarct-related artery (first myocardial infarction and recurrent myocardial infarction, as long as infarct-related artery is occluded for the first time)
- •written informed consent
- •or 30 patients with stable CAD (control group 1) or 30 healthy volunteers regarding cardiovascular diseases (control group 2)
Exclusion Criteria
- •incompetent persons
- •pregnant and lactating
- •moderate to severe renal insufficiency defined by an GFR \< 60 ml/kg/m2
- •missing written consent
- •other reasons complicating a clinical reevaluation and/or coronary angiography
Arms & Interventions
1
- patients with acute ST elevation myocardial infarction and consecutive percutaneous coronary intervention of the infarct-related artery
Intervention: contrast echocardiography
1
- patients with acute ST elevation myocardial infarction and consecutive percutaneous coronary intervention of the infarct-related artery
Intervention: 2D and 3D echocardiography
1
- patients with acute ST elevation myocardial infarction and consecutive percutaneous coronary intervention of the infarct-related artery
Intervention: cardiac MRI
1
- patients with acute ST elevation myocardial infarction and consecutive percutaneous coronary intervention of the infarct-related artery
Intervention: blood sampling
2
- 30 patients with stable CAD (control group 1)
Intervention: blood sampling
3
- 30 healthy volunteers regarding cardiovascular diseases (control group 2)
Intervention: blood sampling
Outcomes
Primary Outcomes
Not specified