Strict Glycemic Control by Insulin Infusion:Observations on Emergency Department Initiation

Temple University1 site in 1 country27 target enrollmentMarch 2007

ConditionsHyperglycemia

InterventionsInsulin

DrugsInsulin

Overview

Phase: Phase 4
Intervention: Insulin
Conditions: Hyperglycemia
Sponsor: Temple University
Enrollment: 27
Locations: 1
Primary Endpoint: Time to Achieve Glycemic Control
Status: Completed
Last Updated: 9 years ago

Overview Investigators Eligibility Criteria Arms & Interventions Outcomes Sites Similar Trials

Overview

Brief Summary

Glycemic control can be safely achieved in surgical and medical intensive care unit settings and has been shown to improve short and long-term clinical outcomes. As such, insulin infusion protocols are routinely used in the ICU setting. The investigators plan to establish the use of strict glycemic control in a heterogenous group of acutely ill patients in the ED setting. The investigators propose to study the aspects of implementing a strict glycemic control protocol in the ED.

Registry

clinicaltrials.gov

Start Date

March 2007

End Date

October 2009

Last Updated

9 years ago

Study Type

Interventional

Study Design

Single Group

Sex

All

Investigators

Sponsor

Temple University

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Patients with blood glucose ≥130 mg% considered to be critically ill as defined by:
•APACHE II score ≥9 (See Appendix 1) OR \>2 SIRS criteria with lactate ≥ 4 or BP \< 90mmHg despite one liter of fluid OR Evidence of Organ Dysfunction (see Appendix 1)

Exclusion Criteria

•Patients requiring urgent interventional procedure (e.g. cardiac catheterization, dialysis) or surgery performed outside of the ED.

Arms & Interventions

A

All subjects placed on insulin infusion.

Intervention: Insulin

Outcomes

Primary Outcomes

Time to Achieve Glycemic Control

Time Frame: Study duration 6 hours. Blood glucose checked at 30 minutes then every 15 minutes until within target blood glucose range then every hour.