A phase I/II trial of concurrent thoracic radiotherapy with the combination of cisplatin and nab-pacliaxel for locally advanced non-small cell lung cancer
Phase 1
- Conditions
- locally advanced non-small cell lung cancer
- Registration Number
- JPRN-UMIN000012531
- Lead Sponsor
- Department of Medical Oncology, Kindai University, Faculty of Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 25
Inclusion Criteria
Not provided
Exclusion Criteria
1) Pulmonary disorder (idiopathic pulmonary fibrosis, interstitial lung disease, pneumoconiosis, active radiation pneumonia, etc.). 2) SVC syndrome 3) With active infection 4) With active double cancer. 5) With other serious disease condition (bleeding, cardiac diseases, poorly controlled diabetes, etc.) 6) Clinically significant drug allergy 7) Patients with steroid treatment. 8) Uncontrolled psychiatric disease. 9) Pregnancy or lactating patients 10) Positive serum HBs antigen or HCV antibody 11) Others
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method phase 1:determine the recommended dose phase 2:2year survival rate
- Secondary Outcome Measures
Name Time Method phase 1:safety, response rate, 2year survival rate, progression free survival, completion rate of chemoradiotherapy phase 2:safety, response rate, progression free survival, completion rate of chemoradiotherapy