Anticariogenic Properties of Zamzam Water

Not Applicable

Completed

• Conditions: Caries Active; Caries,Dental

• Registration Number: NCT06538532
• Lead Sponsor: Al-Azhar University

Brief Summary

The present study aims to evaluate and compare the effect of Zamzam water as mouthwashes in high caries-risk patients regarding:

i. Streptococcus mutans (S. mutans) count. ii. Oral pH. After 3 and 6 months interval.

Detailed Description

The present study aims to evaluate and compare the effect of Zamzam water mouthwashes in high caries-risk patients regarding:

i. Streptococcus mutans (S. mutans) count. ii. Oral pH. all patients will be into two groups; The first group will use Zamzam water mouthwash for a six months with other preventive protocols including fissure sealants and preventive restorations wherever needed, while the second group will undergo preventive protocols only. During these six months, patients will be reassessed at three and six-month intervals regarding S. mutans count, oral pH, and caries risk level.

Study Timeline

• Study Start: 2023-06-01
• Primary Completion: 2024-03-01
• Study Completion: 2024-06-01
• Study First Submitted: 2024-07-25
• Status Verified: 2024-08
• Study First Submitted QC: 2024-08-02
• Study First Posted: 2024-08-05
• Last Update Submitted: 2024-08-25
• Last Update Posted: 2024-08-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

• Male or female participants aged between 18-35 years.
• Systemically- free individuals.
• High caries-risk patients according to ADA (American Dental Association).
• Not on a medication interfering with salivary secretion.
• Co-operative patients approved to participate in the study.

Exclusion Criteria

• Patients who are already on any mouthwash regime.
• Patients who are on any medication that would alter the salivary secretion.
• Allergy to any of the ingredients of the study products.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
caries risk level	3 months and 6 months	According to ADA
Streptomutans count	3 months and 6 months	measurements of Colony forming unit (CFU) will be performed using blood agar and mitis salivarius-bacitracin agar (MSBA).
Salivary PH level	3 months and 6 months	using pH meter

Trial Locations

Locations (1)

Faculty of Dental medicine for Girls Al Azhar university; 🇪🇬 Cairo, Egypt