The Possible Effect of Quercetin on Prophylaxis and Treatment of COVID-19
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 447
- 试验地点
- 1
- 主要终点
- Standardized Mortality rate
研究概览
简要总结
Novel Coronavirus is defined to be the cause of COVID-19, recently. It's known that COVID-19 goes with excessive immune reaction of human body in severe cases. The investigators hypothesize that quercetin, as a strong scavenger and anti-inflammatory agent, can be effective on both prophylaxis and treatment of COVID-19 cases. Therefore, the aim of this study to evaluate the possible role of quercetin on prophylaxis and treatment of COVID-19.
详细描述
Novel Coronavirus is defined to be the cause of COVID-19, recently. It's known that COVID-19 goes with excessive immune reaction of human body in severe cases. Quercetin is reported to be effective on treatment and prophylaxis of other SARS like coronavirus infections, as a strong antioxidant and scavenger flavonoid without any adverse events. Upon this data, the investigators hypothesize that quercetin can be effective on both prophylaxis and treatment of COVID-19 cases. Therefore, the aim of this study to evaluate the possible role of quercetin on prophylaxis and treatment of COVID-19.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •moderate-high risk for COVID-19
- •obtained informed consent
排除标准
- •declined to participate
- •genetic/chromosomal abnormalities
- •any kind of sensitivity or allergy for quercetin
- •history of previous hypersensitivity with quercetin
研究组 & 干预措施
non-quercetin group
Participants, who accept to enroll the study without having quercetin prophylaxis and who do not have a history of COVID-19, will be in this group.
quercetin prophylaxis group
Participants, who takes a daily dose of 500mg quercetin and who not have a history of COVID-19, will be in this group.
干预措施: Quercetin Prophylaxis (Dietary Supplement)
quercetin treatment group
Participants, who takes a daily dose of 1000mg quercetin and who are proven cases for COVID-19, will be in this group.
干预措施: Quercetin Treatment (Dietary Supplement)
结局指标
主要结局
Standardized Mortality rate
时间窗: 3 months
Mortality rate will be compared between two groups
Prevalence of COVID-19 calculated using a questionnaire
时间窗: 3 months
Prevalence of COVID-19 in prophylaxis and sham group will be calculated using a questionnaire including hospital records
次要结局
- Morbidity rate(3 months)
研究者
Hasan Onal
Professor
Kanuni Sultan Suleyman Training and Research Hospital