Effect of Quercetin on Prophylaxis and Treatment of COVID-19

Not Applicable

Completed

• Conditions: COVID-19
• Interventions: Dietary Supplement: Quercetin Prophylaxis; Dietary Supplement: Quercetin Treatment

• Registration Number: NCT04377789
• Lead Sponsor: Kanuni Sultan Suleyman Training and Research Hospital

Brief Summary

Novel Coronavirus is defined to be the cause of COVID-19, recently. It's known that COVID-19 goes with excessive immune reaction of human body in severe cases. The investigators hypothesize that quercetin, as a strong scavenger and anti-inflammatory agent, can be effective on both prophylaxis and treatment of COVID-19 cases. Therefore, the aim of this study to evaluate the possible role of quercetin on prophylaxis and treatment of COVID-19.

Detailed Description

Novel Coronavirus is defined to be the cause of COVID-19, recently. It's known that COVID-19 goes with excessive immune reaction of human body in severe cases. Quercetin is reported to be effective on treatment and prophylaxis of other SARS like coronavirus infections, as a strong antioxidant and scavenger flavonoid without any adverse events. Upon this data, the investigators hypothesize that quercetin can be effective on both prophylaxis and treatment of COVID-19 cases. Therefore, the aim of this study to evaluate the possible role of quercetin on prophylaxis and treatment of COVID-19.

Study Timeline

• Study Start: 2020-03-20
• Study First Submitted: 2020-05-01
• Study First Submitted QC: 2020-05-05
• Study First Posted: 2020-05-06
• Primary Completion: 2020-07-31
• Study Completion: 2020-08-31
• Status Verified: 2021-02
• Last Update Submitted: 2021-02-17
• Last Update Posted: 2021-02-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 447

Inclusion Criteria

• moderate-high risk for COVID-19
• obtained informed consent

Exclusion Criteria

• declined to participate
• genetic/chromosomal abnormalities
• any kind of sensitivity or allergy for quercetin
• history of previous hypersensitivity with quercetin

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
quercetin prophylaxis group	Quercetin Prophylaxis	Participants, who takes a daily dose of 500mg quercetin and who not have a history of COVID-19, will be in this group.
quercetin treatment group	Quercetin Treatment	Participants, who takes a daily dose of 1000mg quercetin and who are proven cases for COVID-19, will be in this group.

Primary Outcome Measures

Name	Time	Method
Prevalence of COVID-19 calculated using a questionnaire	3 months	Prevalence of COVID-19 in prophylaxis and sham group will be calculated using a questionnaire including hospital records
Standardized Mortality rate	3 months	Mortality rate will be compared between two groups

Secondary Outcome Measures

Name	Time	Method
Morbidity rate	3 months	Morbidity rates besides recovery rates from COVID-19 will be documented

Trial Locations

Locations (1)

Kanuni Sultan Suleyman Training and Research Hospital; 🇹🇷 Istanbul, Turkey