A Pilot Trial of Vorinostat Plus Tacrolimus and Methotrexate to Prevent Graft Versus Host Disease Following Unrelated Donor Hematopoietic Stem Cell Transplantation
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- The Number of Participants That Experience Grade 2-4 Acute GVHD (Graft Versus Host Disease) by Day 100
研究概览
简要总结
This pilot phase II trial studies how well giving vorinostat, tacrolimus, and methotrexate works in preventing graft-versus-host disease (GVHD) after stem cell transplant in patients with hematological malignancies. Vorinostat, tacrolimus, and methotrexate may be an effective treatment for GVHD caused by a bone marrow transplant.
详细描述
PRIMARY OBJECTIVES:
I. To assess the safety and the feasibility of the addition of vorinostat to tacrolimus and methotrexate GVHD prophylaxis.
SECONDARY OBJECTIVES:
I. To determine day 100 grades 2-4 acute GVHD. II. To determine 1-year overall survival and relapse-free survival. III. To correlate plasma concentrations of inflammatory markers of acute GVHD. IV. To correlate protein acetylation in peripheral blood mononuclear cells before and after administration of vorinostat.
OUTLINE:
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •A prospective patient for allogeneic HSCT for hematologic conditions, both malignant and non-malignant; donor can be unrelated marrow or peripheral blood cells; a patient with history of central nervous system (CNS) involvement is eligible if CNS disease is in remission at time of study consideration
- •The donor and recipient must have a human leukocyte antigen (HLA)-8/8 allelic match at the HLA-A, -B, -C, and -DRB1; high-resolution typing is required for all alleles
- •Diagnoses to be included:
- •Acute myelogenous leukemia at the following stages:
- •First remission
- •Second or subsequent remission
- •Complete remission is defined as the absence of blasts in the peripheral circulation at the time of enrollment and < 5% blasts in the bone marrow
- •Chronic myelogenous leukemia at the following stages:
- •First or subsequent chronic phase:
- •Patient refused tyrosine kinase therapy or is otherwise not suited for it
- •Stable, not hematologic remission: blasts present in marrow and/or peripheral blood, but disease does not qualify as accelerated or blast phase
- •Hematologic remission: no blast cells or precursor cells in the blood or marrow
- •Partial cytogenetic remission: Philadelphia chromosome positive (Ph+) metaphases > 0% but < 35%
- •Complete cytogenetic remission: absence of Ph+ metaphases
- •Accelerated phase - any one of the following symptoms:
- •White blood cells (WBC) difficult to control (> 50 x 10^9/L despite therapy)
- •Rapid doubling of WBC (< 5 days)
- •10% blasts in blood or marrow
- •20% blasts and/or promyelocytes in blood or marrow
- •20% basophils and/or eosinophils in blood
- •Anemia or thrombocytopenia unresponsive to standard treatment
- •Persistent thrombocytosis (> 1000 x 10^9/L)
- •Cytogenetic abnormalities in addition to Ph+
- •Increasing splenomegaly
- •Marrow fibrosis
- •Myelodysplastic syndromes at any of the following stages:
- •Refractory anemia
- •Refractory anemia with ringed sideroblasts
- •Refractory cytopenia with multilineage dysplasia
- •Refractory cytopenia with multilineage dysplasia and ringed sideroblasts
- •Refractory anemia with excess blasts-1 (5-10% blasts)
- •Refractory anemia with excess blasts-2 (10-20% blasts)
- •Myelodysplastic syndrome, unclassified
- •Myelodysplastic syndrome (MDS) associated with isolated del (5q)
- •Chronic myelomonocytic leukemia
- •Primary Myelofibrosis
- •Intermediate-2 risk or high risk disease
- •Patients should have extinguished standard of care options prior to being considered for this trial
- •Chronic lymphocytic leukemia
- •Complete remission: the disease is completely absent and no relapse occurred prior to the preparative regimen; requires all of the following:
- •Nodular partial remission: complete response with persistent lymphoid nodules in bone marrow
- •Partial remission: reduction of more than 50% in the disease burden regardless of the number of lines of therapy received
- •Mature B cell malignancies
- •Patients should have extinguished standard of care options prior to being considered eligible for this trial
- •First complete remission (CR1) confirmed: complete disappearance of all known disease; the term "confirmed" is defined as a laboratory and/or pathological or radiographic determination.
- •CR1 unconfirmed (CRU1): complete disappearance of all known disease with the exception of persistent scan abnormalities of unknown significance; the term "unconfirmed" is defined as scan abnormalities of unknown significance that are not biopsied or otherwise evaluated
- •Second or subsequent complete remission (CR2+) confirmed: the recipient relapsed, then achieved complete absence of disease without radiographic evidence of disease
- •CR2+ unconfirmed: the recipient has achieved a second or subsequent complete response but has persistent radiographic abnormalities of unknown significance.
- •Partial remission: reductions of >= 50% in greatest diameter of all sites of known disease and no new sites
- •Karnofsky >= 70%
- 另有 11 项未显示
排除标准
- •Patients who are not a candidate for an unrelated donor allogeneic HSCT based on the current institutional bone marrow transplant (BMT) program clinical practice guidelines; organ function criteria will be utilized per the current institutional BMT program clinical practice guidelines; there will be no restriction to study entry based on hematological parameters
- •History of allergic reactions attributed to compounds of similar chemical or biologic composition to vorinostat
- •Patients undergoing a total body irradiation (TBI)-based conditioning regimen (TBI 1200 centigray [cGy])
- •Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements; patients still under therapy for presumed or proven infection are eligible provided there is clear evidence (radiographic findings and/or culture results) that the infection is well-controlled; patients under treatment for infection will be enrolled only after clearance from the Principal Investigator (PI)
- •Pregnant women are excluded from this study because vorinostat is a histone deacetylase inhibitor agent with the potential for teratogenic or abortifacient effects; because there is an unknown but potential risk for adverse events in nursing infants secondary to treatment of the mother with vorinostat, breastfeeding should be discontinued if the mother is treated with vorinostat
- •Patients with evidence of human immunodeficiency virus (HIV) seropositivity and/or positive polymerase chain reaction (PCR) assay, human T-lymphotropic virus (HTLV)1/HTLV2 seropositivity; the safety of allogeneic HSCT is not yet well-established for this population
- •Patients with evidence of hepatitis B or hepatitis C PCR positivity; hepatitis reactivation following myelosuppressive therapy can lead to fatal complications
- •Patients with a history of prolonged corrected QT interval (QTc) syndrome
- •Patients asking or who have had prior treatment with a drug like vorinostat (i.e., valproic acid) within the last 30 days
研究组 & 干预措施
Supportive care (vorinostat, tacrolimus, methotrexate)
Patients receive vorinostat PO BID on days -10 to 100. Beginning on day -3, patients receive tacrolimus IV continuously or PO BID (or cyclosporine IV continuously or PO in patients unable to tolerate tacrolimus) with taper on days 100-180.Patients also receive methotrexate IV QD on days 1, 3, 6, and 11.
干预措施: vorinostat (Drug)
Supportive care (vorinostat, tacrolimus, methotrexate)
Patients receive vorinostat PO BID on days -10 to 100. Beginning on day -3, patients receive tacrolimus IV continuously or PO BID (or cyclosporine IV continuously or PO in patients unable to tolerate tacrolimus) with taper on days 100-180.Patients also receive methotrexate IV QD on days 1, 3, 6, and 11.
干预措施: tacrolimus (Drug)
Supportive care (vorinostat, tacrolimus, methotrexate)
Patients receive vorinostat PO BID on days -10 to 100. Beginning on day -3, patients receive tacrolimus IV continuously or PO BID (or cyclosporine IV continuously or PO in patients unable to tolerate tacrolimus) with taper on days 100-180.Patients also receive methotrexate IV QD on days 1, 3, 6, and 11.
干预措施: cyclosporine (Drug)
Supportive care (vorinostat, tacrolimus, methotrexate)
Patients receive vorinostat PO BID on days -10 to 100. Beginning on day -3, patients receive tacrolimus IV continuously or PO BID (or cyclosporine IV continuously or PO in patients unable to tolerate tacrolimus) with taper on days 100-180.Patients also receive methotrexate IV QD on days 1, 3, 6, and 11.
干预措施: methotrexate (Drug)
Supportive care (vorinostat, tacrolimus, methotrexate)
Patients receive vorinostat PO BID on days -10 to 100. Beginning on day -3, patients receive tacrolimus IV continuously or PO BID (or cyclosporine IV continuously or PO in patients unable to tolerate tacrolimus) with taper on days 100-180.Patients also receive methotrexate IV QD on days 1, 3, 6, and 11.
干预措施: laboratory biomarker analysis (Other)
Supportive care (vorinostat, tacrolimus, methotrexate)
Patients receive vorinostat PO BID on days -10 to 100. Beginning on day -3, patients receive tacrolimus IV continuously or PO BID (or cyclosporine IV continuously or PO in patients unable to tolerate tacrolimus) with taper on days 100-180.Patients also receive methotrexate IV QD on days 1, 3, 6, and 11.
干预措施: pharmacological study (Other)
结局指标
主要结局
The Number of Participants That Experience Grade 2-4 Acute GVHD (Graft Versus Host Disease) by Day 100
时间窗: Day 100
The incidence of grade 2-4 acute GVHD (Graft Versus Host Disease) by day 100 Grade 2 GVHD: Maculopapular rash covering 25-50% of BSA (Body Surface Area), bilirubin between 3.1-6 mg/dl, and/ or adult stool output between 1000-1500 ml/day (child between 20-30 ml/kg/day). Grade 3 GVHD: Maculopapular rash covering \>50% of BSA, bilirubin between 6.1-15 mg/dl, and/ or adult stool output \>1500 ml/day (child \>30 ml/kg/day). Grade 4 GVHD: Generalized erythroderma plus bullous formation and desquamation \>5% BSA, bilirubin \>15 mg/dl, and/ or severe abdominal pain with or without ileus, or grossly bloody stool.
次要结局
- Mean Percent of Planned Dose Administered(Up to day 30)
- The Percentage of Patients Alive Without GVHD or Use of Steroids(Up to 1 year)
- The Percentage of Patients Alive at 1 Year(Up to 1 year)
- Median Ac-H3 Levels in Patients Treated With Vorinostat and Patients Not Treated With Vorinostat(Up to day 100)
- The Percentage of Patients With Relapse at 1 Year(Up to 1 year)
- Median Plasma Concentration of IL-6 in Patients Treated With Vorinostat and Patients Not Treated With Vorinostat(Up to day 100)