Isocapnic intermittent hypoxia and endothelial dysfunctio

Phase 3

Recruiting

• Conditions: Healthy control subjects; Other -

• Registration Number: ACTRN12605000280606
• Lead Sponsor: HMRC

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2005-09-02
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: Male
• Target Recruitment: 10

Inclusion Criteria

Healthy men

Exclusion Criteria

History of obstructive sleep apnoea or cardiovascular or respiratory disease, Smoker, Treatment with cardiovascular or respiratory medication.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To measure the effect of LNMMA, a nitric oxide synthase inhibitor, on the change in AIx (an index of arterial stiffness), with hypoxic exposure[Measured continuously during the 50 minute protocol.]

Secondary Outcome Measures

Name	Time	Method
Changes in heart rate[ This will be measured continously during the 50 minute protocol.];Changes in blood pressure[ This will be measured continously during the 50 minute protocol.];Changes in peripheral arterial tonometry[ This will be measured continously during the 50 minute protocol.];Changes in ventilation with hypoxic exposure.[ This will be measured continously during the 50 minute protocol.]