A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Effects of Bioavailable Turmeric Extract on Biological Aging in Healthy Adults
试验速览
- 阶段
- 2 期
- 状态
- 进行中（未招募）
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Mean change in inflammatory and oxidative stress biomarkers
研究概览
简要总结
We hypothesize that supplementation with bioavailable curcumin will improve markers of healthy ageing by reducing oxidative stress and systemic inflammation, supporting cognitive and physical performance, and promoting overall physiological resilience in healthy adults. The study will assess parameters that are mechanistically linked to ageing, including: Inflammatory markers to evaluate curcumin’s anti-inflammatory effect, Oxidative stress biomarkers to determine antioxidant capacity, Cognitive and physical function assessments to measure real-world implications of healthy ageing and Quality of life scores to assess subjective wellbeing. These parameters will help us comprehensively explore the healthy ageing potential of curcumin and provide translational evidence to support its use as a safe, nutraceutical intervention for longevity and improved life quality.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant, Investigator, Outcome Assessor and Date-entry Operator Blinded
入排标准
- 年龄范围
- 50.00 Year(s) 至 70.00 Year(s)（—）
- 性别
- All
入选标准
- •Males or female participants aged 50 years to 70 years
- •No clinically diagnosed chronic diseases
- •Normal blood pressure (SBP less than than 140 mmHg, DBP less than 90 mmHg)
- •Normal fasting blood glucose (less than or equal to 100 mg/dL)
- •Normal lipid profile (Total cholesterol less than 200 mg/dL, LDL less than 150 mg/dL, HDL greater than 40 mg/dL, Triglycerides less than 150 mg/dL)
- •BMI 18.5 – 29.9 kg/m²
- •Willingness to provide informed consent and comply with study procedures.
排除标准
- •Clinically diagnosed conditions (hypertension, diabetes, cardiovascular disease, metabolic disorders)
- •Use of anti-inflammatory, antioxidant, or immune-modulating medications/supplements within 30 days before study enrolment
- •Major surgery or hospitalization in the past six months
- •Participation in another clinical trial within three months
- •Smoking or excessive alcohol consumption (greater than 2 standard drinks/day)
- •Any condition that may interfere with study compliance or data interpretation.
结局指标
主要结局
Mean change in inflammatory and oxidative stress biomarkers
时间窗: Baseline, Day 30, Day 60
次要结局
- Mean change in other metabolic and age-related biomarkers(Baseline, Day 30, Day 60)
- Mean change in scores of the assessment questionnaires(Baseline, Day 30, Day 60)
研究者
Dr Binu T Kuruvilla
Arjuna Natural Private Limited