A Phase II Study of the Rate of Conversion to Complete Resection in Patients With Initially Inoperable Hepatic-Only Metastases From Colorectal Cancer After Treatment With Hepatic Arterial Infusion With Floxuridine and Dexamethasone in Combination With Best Systemic Chemotherapy
试验速览
- 阶段
- 2 期
- 状态
- 进行中（未招募）
- 入组人数
- 64
- 试验地点
- 6
- 主要终点
- Resectability rate
研究概览
简要总结
RATIONALE: Hepatic arterial infusion uses a catheter to carry tumor-killing substances directly into the liver. Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving floxuridine and dexamethasone directly into the arteries around the tumor together with combination chemotherapy may kill more tumor cells.
PURPOSE: This phase II trial is studying how well hepatic arterial infusion with floxuridine and dexamethasone works when given together with combination chemotherapy in treating patients with colorectal cancer that has spread to the liver.
详细描述
OBJECTIVES:
Primary
- Assess the rate of conversion to complete resection in patients with initially unresectable colorectal cancer metastatic to the liver treated with hepatic arterial infusion comprising floxuridine and dexamethasone in combination with systemic irinotecan hydrochloride and either oxaliplatin or leucovorin calcium/fluorouracil.
Secondary
- Evaluate the time to progression in patients treated with this regimen.
- Evaluate disease-free survival of patients treated with this regimen.
- Evaluate overall survival of patients treated with this regimen.
- Determine the response rate (complete, partial, and moderate response) in patients treated with this regimen.
- Evaluate the safety profile and tolerability of this regimen in these patients.
- Assess the expression pattern of the VEGF receptor VEGFR1, VEGFR2, and VEGFR3 and their cognate ligands (i.e., VEGF-A, VEGF-B, VEGF-C, VEGF-D, and P1GF) in patients treated with this regimen.
- Correlate circulating angiogenic markers with tumor resectability, disease progression, and patient survival.
- Procure normal and diseased liver tissue for evaluation of thymidylate synthase, p53 gene, p21, topoisomerase 1, dihydropyrimidine dehydrogenase, and excision repair cross-complementing gene levels.
- Assess the expression pattern of tissue factor (TF) and explore its correlation with the TF receptors PAR-1, PAR-2, TF regulators PTEN, k-ras, b- raf, p53, and outcome.(Closed as of 11/30/10)
- Assess the prognostic and predictive role of preoperative, pretreatment, and during treatment serum TF in regards to outcome (progression-free survival and overall survival) and response to treatment with this regimen and to salvage treatments such as EGFR-inhibitors.(Closed as of 11/30/10)
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 120 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •DISEASE CHARACTERISTICS:
- •Histologically confirmed colorectal adenocarcinoma metastatic to the liver
- •Previously treated or untreated disease
- •No clinical or radiographic evidence of extrahepatic disease
- •Primary tumor may be present at study registration provided it is not obstructing the intestinal lumen or is significantly bleeding
- •If present, the primary tumor will be resected at the time of pump placement
- •Must have inoperable liver metastases confirmed by 2-3 hepatobiliary surgeons and the assigned radiologist
- •Liver metastases < 70% of the liver parenchyma
- •Inoperable liver metastases is defined by one of the following:
- •More than 6 metastases in a single lobe with one lesion ≥ 5 cm
- •At least 6 metastases distributed diffusely in both lobes of the liver
- •When a margin-negative resection would require resection of all three hepatic veins, both portal veins, or the retrohepatic vena cava
- •Requires a resection that leaves < 2 hepatic segments (not including the caudate lobe) behind with adequate arterial or portal inflow, venous outflow, and biliary drainage
- •No ascites or hepatic encephalopathy
- •No history of primary CNS tumors
- •PATIENT CHARACTERISTICS:
- •Karnofsky performance status 60-100%
- •WBC ≥ 3,000/mm^3
- •ANC ≥ 1,500/mm^3
- •Platelet count ≥ 100,000/mm^3
- •INR < 1.5
- •Hemoglobin ≥ 9 g/dL
- •Creatinine ≤ 1.5 mg/dL
- •Total bilirubin ≤ 1.5 mg/dL
- •Not pregnant or nursing
- •Negative pregnancy test
- •Fertile patients must use effective contraception
- •Physically able to tolerate major partial hepatectomy
- •No active infection
- •No concurrent active malignancies, except potentially resectable primary colorectal tumor
- •No bleeding diathesis or coagulopathy
- •No history of serious systemic disease, including any of the following:
- •Myocardial infarction within the past 6 months
- •Uncontrolled hypertension (i.e., blood pressure > 150/100 mm Hg on medication)
- •Unstable angina
- •New York Heart Association class II-IV congestive heart failure
- •Unstable symptomatic arrhythmia requiring medication
- •Chronic atrial arrhythmia (i.e., atrial fibrillation or paroxysmal supraventricular tachycardia) allowed
- •Peripheral vascular disease ≥ grade 2
- •No serious or nonhealing active wound, ulcer, or bone fracture
- •No history of seizures not well controlled with standard medical therapy
- •No stroke or transient ischemic attack within the past 6 months
- •No concurrent obstruction of the gastrointestinal or genitourinary tract
- •PRIOR CONCURRENT THERAPY:
- •At least 4 weeks since prior radiotherapy to the pelvis
- •Prior chemotherapy allowed
- •No prior radiotherapy, hepatic thermal ablation, or resection (other than biopsy) to the liver
- •No prior floxuridine
- •No prior hepatic arterial infusion
- •No concurrent chronic aspirin (> 325 mg/day) or nonsteroidal anti-inflammatory medications known to inhibit platelet function
- 另有 1 项未显示
排除标准
- 未提供
研究组 & 干预措施
Group 1
Patients receive hepatic arterial infusion (HAI) therapy comprising floxuridine and dexamethasone continuously on days 1-14. Patients also receive oxaliplatin IV over 2 hours and irinotecan hydrochloride IV over 30 minutes on days 1 and 15. Courses repeat every 4 weeks in the absence of disease progression or unacceptable toxicity.
干预措施: dexamethasone (Drug)
Group 1
Patients receive hepatic arterial infusion (HAI) therapy comprising floxuridine and dexamethasone continuously on days 1-14. Patients also receive oxaliplatin IV over 2 hours and irinotecan hydrochloride IV over 30 minutes on days 1 and 15. Courses repeat every 4 weeks in the absence of disease progression or unacceptable toxicity.
干预措施: floxuridine (Drug)
Group 1
Patients receive hepatic arterial infusion (HAI) therapy comprising floxuridine and dexamethasone continuously on days 1-14. Patients also receive oxaliplatin IV over 2 hours and irinotecan hydrochloride IV over 30 minutes on days 1 and 15. Courses repeat every 4 weeks in the absence of disease progression or unacceptable toxicity.
干预措施: irinotecan hydrochloride (Drug)
Group 1
Patients receive hepatic arterial infusion (HAI) therapy comprising floxuridine and dexamethasone continuously on days 1-14. Patients also receive oxaliplatin IV over 2 hours and irinotecan hydrochloride IV over 30 minutes on days 1 and 15. Courses repeat every 4 weeks in the absence of disease progression or unacceptable toxicity.
干预措施: oxaliplatin (Drug)
Group 2
Patients receive HAI therapy as in group 1. Patients also receive irinotecan hydrochloride IV over 30 minutes and leucovorin calcium IV over 30 minutes on days 1 and 15 and fluorouracil IV continuously over 48 hours on days 1, 2, 15, and 16. Courses repeat every 4 weeks in the absence of disease progression or unacceptable toxicity.
干预措施: dexamethasone (Drug)
Group 2
Patients receive HAI therapy as in group 1. Patients also receive irinotecan hydrochloride IV over 30 minutes and leucovorin calcium IV over 30 minutes on days 1 and 15 and fluorouracil IV continuously over 48 hours on days 1, 2, 15, and 16. Courses repeat every 4 weeks in the absence of disease progression or unacceptable toxicity.
干预措施: floxuridine (Drug)
Group 2
Patients receive HAI therapy as in group 1. Patients also receive irinotecan hydrochloride IV over 30 minutes and leucovorin calcium IV over 30 minutes on days 1 and 15 and fluorouracil IV continuously over 48 hours on days 1, 2, 15, and 16. Courses repeat every 4 weeks in the absence of disease progression or unacceptable toxicity.
干预措施: fluorouracil (Drug)
Group 2
Patients receive HAI therapy as in group 1. Patients also receive irinotecan hydrochloride IV over 30 minutes and leucovorin calcium IV over 30 minutes on days 1 and 15 and fluorouracil IV continuously over 48 hours on days 1, 2, 15, and 16. Courses repeat every 4 weeks in the absence of disease progression or unacceptable toxicity.
干预措施: irinotecan hydrochloride (Drug)
Group 2
Patients receive HAI therapy as in group 1. Patients also receive irinotecan hydrochloride IV over 30 minutes and leucovorin calcium IV over 30 minutes on days 1 and 15 and fluorouracil IV continuously over 48 hours on days 1, 2, 15, and 16. Courses repeat every 4 weeks in the absence of disease progression or unacceptable toxicity.
干预措施: leucovorin calcium (Drug)
结局指标
主要结局
Resectability rate
时间窗: 2 years
次要结局
- Antitumor activity(2 years)
- Response rate(2 years)
- Median time to progression(2 years)
- Survival(2 years)