The effects of Posture and Continuous Positive Airway Pressure (CPAP) on lung function in patients recovering from an acute exacerbation of heart failure

Not Applicable

• Conditions: Heart Failure; Cardiovascular - Other cardiovascular diseases; Respiratory - Other respiratory disorders / diseases

• Registration Number: ACTRN12610000556044
• Lead Sponsor: Professor Matthew Naughton

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2010-07-09
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Patients admitted to The Alfred with the diagnosis of an exacerbation of cardiac failure
Previous diagnosis of heart failure based on echocardiography
Stable clinical status: Respiratory Rate<35, oxygen saturation via pulse oximetry (SpO2) > 84% on room air, systolic blood pressure >90mmHg, clinically well perfused and able to talk sentences
Co-operative, able to give consent

Exclusion Criteria

Pregnancy
History of chronic lung disease requiring long term (>4 weeks) treatment
Severe renal (requiring dialysis) or neurological disease
Recent myocardial infarction (< 6 weeks)
Require intravenous inotropes

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
ung reactance and compliance as measured by the forced oscillation technique[Daily during admission from time of randomisation and on day 30 post discharge.];Change in respiratory function tests (as a composite end point) including: forced expiratory time and vital capacity via spirometry, static lung volumes via body plethysmography and inert gas washout, gas transfer via the diffusing capacity of the lung for carbon monoxide (DLCO) method and respiratory muscle strength via maximal inspiratory and expiratory mouth pressures.[At days 2-4 of admission and then on discharge and on day 30 post discharge.];Lung heterogeneity via the nitrogen multi-breath washout technique[At days 2-4 of admission and then on discharge and on day 30 post discharge.]

Secondary Outcome Measures

Name	Time	Method
Change in clinical parameters (oxygen saturation and heart rate via pulse oximetry, respiratory rate clinically, blood pressure via automatic sphygmomanometer)[Daily during admission from time of randomisation and on day 30 post discharge.];change in BORG dyspnoea score[Daily during admission from time of randomisation and on day 30 post discharge.]