Effect of Transcranial Direct Current Stimulation (tDCS) on Inflammatory Biomarkers in Chronic Schizophrenia: A Randomised Double-Blind Controlled Trial.
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Chronic Schizophrenia
- Sponsor
- All India Institute of Medical Sciences, Bhubaneswar
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Change in the IL-6 levels
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
The study is a randomized, double-blind, parallel-arm, sham-controlled trial that aims to compare the effects of transcranial direct current stimulation (tDCS) versus sham stimulation on inflammatory markers (IL-6 and TNF-alpha) and clinical outcomes (PANSS, AHRS, CGI-SCH, GAF) in patients with chronic schizophrenia over 10 days of treatment. The primary objective is to assess changes in IL-6 levels, while secondary objectives include evaluating changes in TNF-alpha, symptom scales, and adverse events. The study will be conducted at the psychiatry department of AIIMS Bhubaneswar, with 60 patients aged 18-60 years with moderate-to-severe schizophrenia symptoms randomized to receive either active tDCS (cathode over left temporo-parietal junction, anode over left dorsolateral prefrontal cortex) or sham stimulation. The researchers hope to elucidate the potential immunomodulatory effects of tDCS and its impact on symptoms in chronic schizophrenia, which may lead to more targeted, multifaceted interventions to improve patient outcomes.
Investigators
Dr. Debadatta Mohapatra
Associate Prof
All India Institute of Medical Sciences, Bhubaneswar
Eligibility Criteria
Inclusion Criteria
- •Patients clinically diagnosed with schizophrenia (F20 according to ICD-11) for a period more than 2 years receiving antipsychotics.
- •Moderate to severe symptoms (PANSS score \>75 and/or CGI-SGH score \>4)
- •Patients of both sex 18-60 years
- •Right-handed.
- •Legally authorized representative (LAR) giving voluntary written consent for participation in the study.
Exclusion Criteria
- •Patients with chance of pregnancy.
- •Any psychiatric emergency (e.g. suicidal risk, catatonia, prolonged nutritional deprivation) or others (e.g.: aggression or excitement)
- •Co-morbid neurological disease: i) History of migraine. ii) History of seizure/epilepsy. iii) History of head trauma or organic disease.
- •Any contraindication to tDCS procedure: i) Injury or local lesion in the scalp/head ii) Metallic implants in the head iii) Implanted brain medical devices
- •Left-handed.
Outcomes
Primary Outcomes
Change in the IL-6 levels
Time Frame: 10 days
Secondary Outcomes
- To compare the adverse events reported in both control and intervention groups.(5 days and 10 days)
- Change in the Positive and Negative syndrome Scale(5 days and 10 days)
- Change in the Auditory hallucination rating scale(5 days and 10 days)
- Change in the Clinical global impression- Schizophrenia scale(5 days and 10 days)
- Change in the TNF alpha levels.(10 days)
- Change in the Global Assessment of Functioning scale(5 days and 10 days)