Hematological Indices in Rheumatoid Arthritis and Its Association With Disease Activity and Severity
试验速览
- 阶段
- 不适用
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Assessment of level of Red blood cell distribution width
研究概览
简要总结
Rheumatoid arthritis is a chronic systemic inflammatory and autoimmune disease, characterized by disordered immunity, not regulated cytokines and inflammatory infiltration of the synovial joints. It is the most common inflammatory erosive poly arthritis affecting around 0.5-1% of the worldwide population which leads to joint damage and disability
详细描述
The etiology of Rheumatoid arthritis is complex, it is established that the gene environmental interaction plays critical roles in the pathology of Rheumatoid arthritis, in addition to smoking, lifestyle, and hormones.
The lesion is mainly concentrated in the synovial tissue, cartilage, and bone. Inflammation is the primary cause of joint deformation and limited joint mobility in Rheumatoid arthritis patients. As the disease progresses, the risk of bone damage and cartilage destruction increases, leading to substantial disability.
The activity of the disease in Rheumatoid arthritis patients is assessed by clinical examination, laboratory tests and radio graphic assessment. Laboratory assessment of Rheumatoid arthritis activity is done routinely by measuring acute phase reactants such as an erythrocyte sedimentation rate and C-reactive protein, which are elevated in active Rheumatoid arthritis patients.
Albumin is the major plasma protein and its determination is used for the prognostic assessment of several diseases. It is a routine marker reflecting both nutritional status and systemic inflammation, and the synthesis of albumin can be suppressed by systematic inflammation and malnutrition.
It was reported that the level of albumin was decreased in Rheumatoid arthritis patients. This low concentration of albumin in Rheumatoid arthritis patients may owing to excessive albumin consumption caused by inflammatory substances.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Other
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult RA Patients who fulfilled the 2010 European league against rheumatism criteria for the classification of RA
排除标准
- •Individuals with concomitant other autoimmune diseases
- •RA patients with anemia, pregnancy, postpartum, diabetes, obesity hypertension.
- •Patients with age less than 18 years
- •Patients with end stage organ failure.
- •Patients with liver diseases.
- •Patients with hematological disorders.
- •Patients with malignancies
结局指标
主要结局
Assessment of level of Red blood cell distribution width
时间窗: Through study completion, an average of 1 year
Red blood cell distribution width will be measured.
Assessment of level of serum Albumin in Rheumatoid arthritis patients
时间窗: Through study completion, an average of 1 year
The level of serum Albumin will be measured in Rheumatoid arthritis patients
次要结局
- The relation between Red blood cell distribution width and level of serum albumin in RA patients and association with the disease activity and severity.(Through study completion, an average of 1 year)
研究者
Fatma Yassine Meligy
Princible investigator
Assiut University