Urinary Biomarkers as Predictors on Renal Function in Congenital Hydronephrosis

University of Aarhus1 site in 1 country45 target enrollmentNovember 2007

ConditionsUreteral Obstruction

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Ureteral Obstruction
Sponsor: University of Aarhus
Enrollment: 45
Locations: 1
Primary Endpoint: Urinary cytokines
Status: Completed
Last Updated: 13 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The purpose of this study is to detect new urinary biomarkers that can be used as predictors on renal function in congenital hydronephrosis caused by unilateral ureteral obstruction (UUO) and to elucidate the pathophysiology of UUO.

Registry

clinicaltrials.gov

Start Date

November 2007

End Date

January 2012

Last Updated

13 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

University of Aarhus

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Children referred to surgical treatment of congenital hydronephrosis caused by ureteral obstruction.
•Declining function of the hydronephrotic kidney more than 5 %, and to less than 40 % of the total renal function OR ipsilateral flank pain.

Exclusion Criteria

•Bilateral hydronephrosis
•Previous operation in the urinary system except operation for phimosis and other deformations of the external genital organs.
•Deformations in the lower part of the ureter, bladder and urethra. Urinary stones. Reflux. Urinary tract infections \< 6 months.
•Neurogenic bladder dysfunction.
•GFR \< 40 % standardized to age.
•Non-compliance. Linguistic difficulties.