Investigating the effect of simultaneous infusion of lidocaine and ketamine compared to single infusion of lidocaine and ketamine on neuromonitoring in spine surgeries
Phase 3
Recruiting
- Conditions
- euromonitoring status in spine surgeries.Fusion of spineM43.2
- Registration Number
- IRCT20230204057318N2
- Lead Sponsor
- Shahid Beheshti University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 90
Inclusion Criteria
Candidate patients for spine surgery under neuromonitoring
Age 18 to 65 years
Patients with ASA class 1 or 2
Exclusion Criteria
Absence of any significant laboratory disturbance in coagulation, kidney, liver function tests, blood cell count
No history of drug addiction
Insensitivity to ketamine or local anesthetics
Absence of contraindications for performing MEP (epilepsy, cerebral cortex damage, increased intracranial pressure, cardiac pacemaker, intracranial electrodes, or vascular clamps)
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method atency and amplitude changes in neuromonitoring. Timepoint: During surgery. Method of measurement: Analysis of neural wave diagram.
- Secondary Outcome Measures
Name Time Method Intraoperative hemodynamic. Timepoint: During surgery. Method of measurement: Hemodynamic monitoring device.;Intraoperative hemorrhage. Timepoint: During surgery. Method of measurement: Suction bottle and gauzes.;Emergence time from anesthesia. Timepoint: During surgery. Method of measurement: Chronometer.;Pain in the recovery room. Timepoint: Recovery. Method of measurement: Visual Analogue Scale (VAS).;First time of analgesia request. Timepoint: Post surgery. Method of measurement: Watch.;Postoperative nausea and vomiting. Timepoint: Recovery room. Method of measurement: Questionary.;Sedation - agitation status. Timepoint: Recovery room. Method of measurement: Riker Sedation- Agitation Scale.