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A Comparison Study of Oxybutynin and Botulinum Toxin for Neurogenic Detrusor Overactivity

Not Applicable
Completed
Conditions
Spinal Cord Injury
Interventions
Registration Number
NCT01477736
Lead Sponsor
Centro de Reabilitação e Readaptação Dr. Henrique Santillo
Brief Summary

The purpose of this study is to compare the effects of oral oxybutynin and intradetrusor injections of botulinum toxin type A on urodynamic parameters and quality of life in patients with neurogenic detrusor overactivity following spinal cord injury.

Detailed Description

Not available

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
68
Inclusion Criteria
  • Spinal cord injury
  • Detrusor overactivity
  • Age over 18 years
  • Spinal cord injury at least 12 months duration
  • Undergoing regular clean intermittent catheterisation
Exclusion Criteria
  • Pregnancy
  • Desire to become pregnant during the study period
  • Breastfeeding
  • Blood coagulation disorder
  • Neuromuscular transmission disorder
  • Use of any intravesical pharmacologic agents
  • Previous use of botulinum toxin A

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Arm && Interventions
GroupInterventionDescription
Botulinum toxin AOxybutynin-
Botulinum toxin ABotulinum toxin A-
oxybutyninOxybutynin-
oxybutyninBotulinum toxin A-
Primary Outcome Measures
NameTimeMethod
The primary study outcome measure was the variation mean in the number of episodes of urinary incontinence per 24 hours, maximum cystometric capacity, maximum detrusor pressure and bladder complianceBeginning and 24 weeks of the study
Secondary Outcome Measures
NameTimeMethod
The secondary outcome measure was quality of life as measured by the Qualiveen questionnaireBeginning and 24 weeks of the study

Trial Locations

Locations (1)

UNICAMP, Division of Urology

🇧🇷

Campinas, Sao Paulo, Brazil

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