Afferent Neurocardiac Signals, Cue Reactivity, and Cognitive Control
Overview
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- P3b ERP amplitude (in microvolts) elicited from a picture-viewing task
Overview
Brief Summary
Conscious attempts to regulate alcohol use are often undermined by automatic attention and arousal processes activated by alcohol cues, as well as by diminished ability to inhibit in-the-moment behaviors. The current study will examine whether a brief behavioral intervention of slow breathing paced at a resonance frequency of the cardiovascular system can interrupt automatic alcohol cue reactivity and enhance cognitive control in binge drinkers. Results from the proposed study may provide new prevention and intervention targets to interrupt unhealthy drinking behaviors.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 35 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Must report at least 2 binge drinking episodes in the past month
- •Have normal or corrected-to-normal vision
Exclusion Criteria
- •History or presence of serious psychiatric disorders, neurological disorders, or head injury resulting in a loss of consciousness
- •Presence of any serious medical condition
- •Report of more than a few occasions (3-4) of illicit drug use, except for cannabis, in the preceding year
Arms & Interventions
Resonance paced breathing
Active resonance breathing task consisting of synchronizing breathing with a visual pacer (E-Z Air, Thought Technology, Ltd., Plattsburgh, NY) that moves up (inhale) and down (exhale) at the rate of 0.1 Hz (6 breaths per min)
Intervention: Resonance breathing (Behavioral)
Low demand vanilla control
A low-demand cognitive "vanilla" task wherein different colored rectangles are presented for 10 sec each, and participants are instructed to silently count the number of blue rectangles
Intervention: Low demand cognitive task (Behavioral)
Outcomes
Primary Outcomes
P3b ERP amplitude (in microvolts) elicited from a picture-viewing task
Time Frame: Immediate; Difference between the active resonance breathing compared to the low demand cognitive task occurring one week apart
The P3b component of the event-related potential occurring 300-600 ms after stimulus presentation at central and parietal electrode sites during a picture viewing task following a 5-minute course of resonance breathing compared to a low-demand control task
N2 ERP amplitude (in microvolts) elicited from an Alcohol Cued Go/No-Go task
Time Frame: Immediate; Difference between the active resonance breathing compared to the low demand cognitive task occurring one week apart
The N2 component (in microvolts) of the event-related potential occurring 250-350 ms after stimulus presentation at frontal and central electrode sites during an Alcohol Cued Go/No-Go task following a 5-minute course of resonance breathing compared to a low-demand control task
N2pc ERP amplitude (in microvolts) elicited from a visual dot probe detection task
Time Frame: Immediate; Difference between the active resonance breathing compared to the low demand cognitive task occurring one week apart
The N2pc component of the event-related potential occurring 200-275 ms after stimulus presentation at parietal and occipital electrode sites (ipsilateral minus contralateral hemisphere activity) during a modified visual dot probe detection task following a 5-minute course of resonance breathing compared to a low-demand control task
N2 ERP latency (in milliseconds) elicited from an Alcohol Cued Go/No-Go task
Time Frame: Immediate; Difference between the active resonance breathing compared to the low demand cognitive task occurring one week apart
The latency of the N2 component of the event-related potential from frontal and central electrode sites during a picture viewing task following a 5-minute course of resonance breathing compared to a low-demand control task. Latency will be determined using 50% area latency from a difference wave between task conditions
N2pc ERP latency (in milliseconds) elicited from a visual dot probe detection task
Time Frame: Immediate; Difference between the active resonance breathing compared to the low demand cognitive task occurring one week apart
The latency of the N2pc component of the event-related potential from parietal and occipital electrode sites during a visual dot probe detection task following a 5-minute course of resonance breathing compared to a low-demand control task. Latency will be determined using 50% area latency from a difference wave between task conditions
P3b ERP latency (in milliseconds) elicited from a picture-viewing task
Time Frame: Immediate; Difference between the active resonance breathing compared to the low demand cognitive task occurring one week apart
The latency of the P3b component of the event-related potential from central and parietal electrode sites during a picture viewing task following a 5-minute course of resonance breathing compared to a low-demand control task. Latency will be determined using 50% area latency from a difference wave between task conditions
Task accuracy from the behavioral response during the Alcohol Cued Go/No-Go task
Time Frame: Immediate; Difference between the active resonance breathing compared to the low demand cognitive task occurring one week apart
Task accuracy as a percentage of correct behavioral responses to the task during the Alcohol Cued Go/No-Go ERP task following a 5-minute course of resonance breathing compared to a low-demand control task
Reaction time from the behavioral response during the Alcohol Cued Go/No-Go task
Time Frame: Immediate; Difference between the active resonance breathing compared to the low demand cognitive task occurring one week apart
Reaction time for the correct behavioral responses to the task measured in milliseconds during the Alcohol Cued Go/No-Go ERP task following a 5-minute course of resonance breathing compared to a low-demand control task
Task accuracy from the behavioral response during the visual dot probe detection task
Time Frame: Immediate; Difference between the active resonance breathing compared to the low demand cognitive task occurring one week apart
Task accuracy as a percentage of correct behavioral responses to the task during the visual dot probe detection task following a 5-minute course of resonance breathing compared to a low-demand control task
Reaction time from the behavioral response during the visual dot probe detection task
Time Frame: Immediate; Difference between the active resonance breathing compared to the low demand cognitive task occurring one week apart
Reaction time for the correct behavioral responses to the task measured in milliseconds during the visual dot probe ERP task following a 5-minute course of resonance breathing compared to a low-demand control task
Secondary Outcomes
No secondary outcomes reported
Investigators
Brandon Alderman, Ph.D.
Associate Professor and Chair
Rutgers, The State University of New Jersey