Heparin-binding Protein and Heparins
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Changes in the level of Heparin-binding protein
Study Overview
Brief Summary
Heparin-Binding protein is a protein from primary and secretory granluae of white blood cells. It is released when white blood cells become activated and has been advocated as a biomarker for sepsis. The aim of this study is to find out if Heparins in clinical doses can change the level of Heparin-binding protein in plasma.
Detailed Description
Blood samples are taken from patients before and after Heparins in clinical doses. The effects of heparins on Heparin-binding protein concentration in plasma is measured. This is a small observational study.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Cross Sectional
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Planned endovascular treatment of aortic aneurysm or peripheral vascular surgery where unfractionated heparin in >3000 units are given perioperatively
- •Planned subcutaneous low molecular weight heparin as a thromboprophylactic treatment after major surgery or on Intensive Care treated patients.
- •Planned open heart surgery with cardiopulmonary bypass.
Exclusion Criteria
- •Under 18 years
- •Unable to get informed consent from patient or relative
Outcomes
Primary Outcomes
Changes in the level of Heparin-binding protein
Time Frame: Repeated blood sampling during minimum of 1 hour and maximum of 5 hours after given heparin
Blood samples are taken before and after given heparin
Secondary Outcomes
No secondary outcomes reported
Investigators
Halla Halldorsdottir
MD
Karolinska University Hospital