To find out effect of Injection Zoledronic acid for treatment of bone weakening condition in patients having long term liver problems/damage.
Not Applicable
Completed
- Conditions
- Health Condition 1: K746- Other and unspecified cirrhosis ofliver
- Registration Number
- CTRI/2020/03/024247
- Lead Sponsor
- Pt BD Sharma PGIMS Rohtak
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 49
Inclusion Criteria
Either gender adult patients with Osteoporosis with liver cirrhosis
Exclusion Criteria
Hyperparathyroidism
Acute Kidney Injury
Diabetes, Chronic kidney disease
Patients on corticosteroids, antiepileptics, antitubercular drugs
Hyperparathyroidism, malabsorption disorders
Thyroid disorders
Hepatocellular carcinoma/ any other malignancy Postmenopausal, pregnant/lactating
females
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Changes in Bone mineral Density <br/ ><br>2. Fracture risk assessment score (FRAX Score)Timepoint: 1 year
- Secondary Outcome Measures
Name Time Method 1. Incidence of pathological fracture <br/ ><br>2. Effect on quality of life using IOF Quellafo 41, EQ 5D-3L, EQ VAS questionnaires <br/ ><br>3. Changes in biochemical parameters- Vitamin D levels, ALP, 24hours urone calcium levels. <br/ ><br>Timepoint: 1. 1 year <br/ ><br>2. 1 years <br/ ><br>3. 3,6,9,12 months.