NCT00897234已完成不适用
Plasma Quantification of Cathepsin D and FAS in Non-Small Cell Lung Cancer
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 84
- 试验地点
- 1
- 主要终点
- Levels of cathepsin D
研究概览
简要总结
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
PURPOSE: This research study is looking at blood samples from patients with non-small cell lung cancer and from healthy volunteers.
详细描述
OBJECTIVES:
- Measure plasma cathepsin D levels in patients with non-small cell lung cancer and in healthy volunteers using mass spectometry.
- Measure fatty acid synthase levels in these patients and healthy volunteers using mass spectometry.
OUTLINE: Blood samples are collected from patients and healthy volunteers to measure the levels of cathepsin D and fatty acid synthase by proteomic profiling and mass spectrometry.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Non-Small Cell Lung Cancer Patients
- •Documented diagnosis of non-small cell lung cancer, any stage and any time point in the course of treatment (i.e., at diagnosis, during any treatment, and during post treatment surveillance)
- •Measurable disease by CT scan within the past 4 weeks
- •Healthy volunteer
- •Non-smoking, defined as < 5 packs/year history of smoking and cessation of smoking ≥ 6 months ago OR a never smoker
- •Not regularly exposed (i.e., daily) to second-hand smoke
排除标准
- •Severe underlying lung disease (i.e., chronic obstructive pulmonary disease with FEV_1 < 1.0 L, pulmonary fibrosis, bronchiectasis, cystic fibrosis, etc.) as determined by enrolling researcher.
- •Written consent must be given for both subjects and controls.
结局指标
主要结局
Levels of cathepsin D
时间窗: At Routine Follow-Up
Measure plasma CD levels in patients with non-small cell lung cancer and non-smoker healthy controls using mass spectrometry.
次要结局
- Levels of fatty acid synthase (FAS)(At Routine Follow-Up)
- Global microRNA expression(At Routine Follow-Up)
研究者
研究点 (1)
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