Effect of melatonin on refractory seizure of childre
Phase 3
- Conditions
- Refractory seizure.Epilepsy and recurrent seizures
- Registration Number
- IRCT20090412001808N6
- Lead Sponsor
- Sari University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
Age 1 to 21 years with a history of seizure
Seizure is not controlled with at least 3 different anticonvulsants
At least four or more seizure episodes in last month
Exclusion Criteria
Treatable seizure
History of cardiovascular syndromes
Neurodegenerative syndromes
Hepatic and renal dysfunction
History of pseudo seizure
Blindness
Irregular drug use
Unreliable parents
History of vasculitis
Severe and persistent progressive seizure
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Frequency and duration of seizure. Timepoint: Baseline (before intervention), first, second, third and fourth weeks. Method of measurement: Frequency and duration of seizure in day.;Sleep quality. Timepoint: Baseline (before intervention), first, second, third and fourth weeks. Method of measurement: The Pittsburgh Sleep Quality Index (PSQI).
- Secondary Outcome Measures
Name Time Method