The Women's Hormone Intervention Secondary Prevention Pilot Study
- Conditions
- Acute myocardial infarction (MI)Circulatory System
- Registration Number
- ISRCTN62197120
- Lead Sponsor
- Medical Research Council (MRC) (UK)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Female
- Target Recruitment
- 125
Post menopausal women (amenorrhoea for more than 12 months oestrogen deficiency symptoms) or more than 55 years, more than 48 hours and less than 7 days after the onset of acute Myocardial Infarction (MI) (Creatine Kinase [CK] twice upper limit or CKMB above the threshold considered diagnostic for myocardial damage in that centre) plus one of the two additional following criteria:
1. Admission for symptoms of acute myocardial ischaemia
2. Changes on the electrocardiogram supportive of a diagnosis of acute MI, provision of written informed consent
1. Unconfirmed MI
2. Use of HRT currently or previous 12 months, patients for whom clear indications for, of contraindications to, long term HRT
3. Increased risk of thromboembolism
4. Prior history of DVT or PE
5. BMI more than 32
6. Prolonged immobility
7. Known breast or endometrial cancer
8. Post-menopausal bleeding that has not been adequately investigated
9. Presence of non-cardiac condition influencing survival
10. Anticipated inability of the patient to comply with the study procedures
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Reinfarction, readmission, death
- Secondary Outcome Measures
Name Time Method ot provided at time of registration