The Role of Serum Anticholinergic Activity in ACVB Patients

Completed

• Conditions: Acetylcholine; BIS-EEG; Cognition

• Registration Number: NCT00782938
• Lead Sponsor: Heidelberg University

Brief Summary

Drugs with anticholinergic potential increase the risk of postoperative transient and persistent cognitive dysfunction especially in cardiac patients. The investigators main goal is to identify preoperative risk factors and to monitor postoperative patients' state in relation to SAA activity and bilateral BIS-EEG changes.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-05
• Status Verified: 2008-10
• Study First Submitted: 2008-10-30
• Study First Submitted QC: 2008-10-30
• Study First Posted: 2008-10-31
• Primary Completion: 2009-12
• Study Completion: 2010-01
• Last Update Submitted: 2010-01-13
• Last Update Posted: 2010-01-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• written compliance to the study participation
• a good knowledge in German speech
• no red/ green blindness
• no previous neurological and/or psychiatric illness
• good ability to see and to hear
• Mini-Mental-State-Examination (MMSE) better than 25 points

Exclusion Criteria

• no written compliance to the study participation
• bad knowledge in German speech
• red/ green blindness
• previous neurological and/or psychiatric illness
• no ability to see and to hear
• Mini-Mental-State-Examination (MMSE) lower than 25 points

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cognitive dysfunction measured by neurocognitive test battery	3 month postsurgery

Secondary Outcome Measures

Name	Time	Method
SAA, BIS-EEG, descriptive patients' characteristics	24 h postsurgery

Trial Locations

Locations (1)

University of Heidelberg, Department of Anesthesiology, Heidelberg Medical School; 🇩🇪 Heidelberg, BW, Germany